inhibition of acetyltransferase activity. Compound cannot substitute the natural substrate GlcN-1-P. Uncompetitive inhibition, compound interacts with the enzymesubstrate complex.
analog of glucosamine-6-phosphate, inhibits acetylation of glucosamine-6-phosphate competitively and by acting as a surrogate substrate. Inhibition of glucosamine production or suitably activated glucosamine in bacteria leads to disruption of the peptidoglycan structure, which results in softening, bulging, deformation, fragility and lysis of the cells. 50% inhibition of bacterial growth at 2.88 mg/ml
analog of glucosamine-6-phosphate, inhibits acetylation of glucosamine-6-phosphate competitively and by acting as a surrogate substrate. Inhibition of glucosamine production or suitably activated glucosamine in bacteria leads to disruption of the peptidoglycan structure, which results in softening, bulging, deformation, fragility and lysis of the cells. 50% inhibition of bacterial growth at 4 mg/ml
2.5 mM, 81% inhibition of isoenzyme 1, 92% inhibition of isoenzyme 2 and 92.5% inhibition of isoenzyme 3, inhibition by 1.25 mM is reversible upon addition of 2.5 mM dithiothreitol