2.3.1.240: narbonolide synthase

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For detailed information about narbonolide synthase, go to the full flat file.

Reaction

+ 6 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ =

+ 7 CoA + 7 CO2 + 5 NADP⁺ + 2 H2O

Synonyms

methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.240 narbonolide synthase

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Results	in table
6	AA Sequence
4	Application
7	Cloned(Commentary)
3	Cofactor
2	General Information
2	kcat/KM [mM/s]
3	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
30	Organism
6	Pathway
3	PDB ID
3	pH Optimum
4	Protein Variants
3	Purification (Commentary)
3	Reaction
16	Reference
15	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.240 - narbonolide synthase

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(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (narbonolide forming)

The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae. The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239, 10-deoxymethynolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis.