2.3.1.240: narbonolide synthase

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For detailed information about narbonolide synthase, go to the full flat file.

Reaction

+ 6 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ =

+ 7 CoA + 7 CO2 + 5 NADP⁺ + 2 H2O

Synonyms

methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.240 narbonolide synthase

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Results	in table
6	AA Sequence
4	Application
7	Cloned(Commentary)
3	Cofactor
2	General Information
2	kcat/KM [mM/s]
3	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
30	Organism
6	Pathway
3	PDB ID
3	pH Optimum
4	Protein Variants
3	Purification (Commentary)
3	Reaction
16	Reference
15	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.1.240 - narbonolide synthase

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malonyl-CoA + 6 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+

narbonolide + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O

Streptomyces venezuelae

Q9ZGI5; Q9ZGI4; Q9ZGI3; Q9ZGI2; Q9ZGI1

the product narbonolide is an intermediate in the biosynthesis of methymycin

729193