2.3.1.240: narbonolide synthase
This is an abbreviated version!
For detailed information about narbonolide synthase, go to the full flat file.
Reaction
+ 6 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ = + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O
Synonyms
methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV
ECTree
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Cloned
Cloned on EC 2.3.1.240 - narbonolide synthase
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expression in Escherichia coli
expression of functional polyketide synthase modules in Escherichia coli
overexpression of pikromycin modules PikAIII and PIkAIV in Escherichia coli
overexpression of polyketide synthase PikAIII, and polyketide synthase PikAIV in Escherichia coli
the picromycin/methymycin PKS genes (pikAI, PikAII, PikAIII, PikAIV and pikAV) are functionally expressed in the heterologous host Streptomyces lividans, resulting in production of both narbonolide and 10-deoxymethynolide