2.3.1.235: tetracenomycin F2 synthase
This is an abbreviated version!
For detailed information about tetracenomycin F2 synthase, go to the full flat file.
Word Map on EC 2.3.1.235
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2.3.1.235
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actinorhodin
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ketosynthase
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ketoreductase
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glaucescens
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beta-ketoacyl
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angucycline
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enterocin
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maritimus
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actiii
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ketoacyl
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self-malonylation
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fredericamycin
- 2.3.1.235
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actinorhodin
-
ketosynthase
- ketoreductase
- glaucescens
-
beta-ketoacyl
-
angucycline
-
enterocin
- maritimus
-
actiii
-
ketoacyl
-
self-malonylation
-
fredericamycin
Reaction
10 malonyl-CoA
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Synonyms
TCM F2, TCM PKS, TcmK protein, TcmN polyketide cyclase, type II polyketide synthase
ECTree
2.3.1.235 tetracenomycin F2 synthaseAdvanced search results
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Substrates Products on EC 2.3.1.235 - tetracenomycin F2 synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
10 malonyl-CoA
tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O
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the multi-domain polyketide synthase involved in the synthesis of tetracenomycin
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10 malonyl-CoA
tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O
TcmN is a bifunctional protein that catalyzes the regiospecific cyclization of the linear decaketide (bound to the multi-domain polyketide synthase) to tetracenomycin F2 and the O-methylation of tetracenomycin D3 to tetracenomycin B3
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?
10 malonyl-CoA
tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O
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the multi-domain polyketide synthase involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules
tetracenomycin F2 i.e. 4-(3-acetyl-4,5,7,10-tetrahydroxyanthracen-2-yl)-3-oxobutanoic acid
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?
