2.3.1.235: tetracenomycin F2 synthase

This is an abbreviated version!
For detailed information about tetracenomycin F2 synthase, go to the full flat file.

10 malonyl-CoA =

+ 10 CoA + 10 CO2 + 2 H2O

TCM F2, TCM PKS, TcmK protein, TcmN polyketide cyclase, type II polyketide synthase

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Results	in table
65	AA Sequence
2	Cloned(Commentary)
1	General Information
1	Natural Substrates/ Products (Substrates)
3	Organism
5	Pathway
4	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reference
3	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
1	Systematic Name

Engineering on EC 2.3.1.235 - tetracenomycin F2 synthase

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C173A

plasmids carrying the C173A mutation produce no detectable amount of tetracenomycin F2

C173S

plasmids carrying the C173S mutation produce no detectable amount of tetracenomycin F2

H350L/S351A

plasmids carrying the H350L/S351A double mutation produce no detectable amount of tetracenomycin F2

S351A

plasmids carrying the S351A mutation produce high amounts of tetracenomycin F2