2.3.1.17: aspartate N-acetyltransferase

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For detailed information about aspartate N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyltransferase, aspartate, ANAT, aspartate acetyltransferase, aspartate N-acetyltransferase, aspartic acetylase, L-aspartate N-acetyltransferase, NAT, NAT8L

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.17 aspartate N-acetyltransferase

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Results	in table
1	Activating Compound
16	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
3	Crystallization (Commentary)
45	Disease/ Diagnostics
2	General Information
2	IC50 Value
55	Inhibitors
24	Ki Value [mM]
30	KM Value [mM]
11	Localization
10	Metals/Ions
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
17	Organism
2	Pathway
3	pH Optimum
3	pH Range
15	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
17	Reference
25	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
24	Substrates and Products (Substrate)
4	Subunits
19	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

pH Range

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pH Range on EC 2.3.1.17 - aspartate N-acetyltransferase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 8

Rattus norvegicus

-

-

658360

5.2 - 8

Rattus norvegicus

-

about 13% of maximal activity at pH 5.2, about 50% of maximal activity at pH 8.0

486456

6 - 9.5

Homo sapiens

Q8N9F0

the enzymatic activity decreases at pH values below pH 7.5. A fit of the Vmax/Km data to a model which assumes that the protonation of a single group leads to loss of activity results in a pK value of 6.8 for a group that must be ionized for the enzyme to remain catalytically active. By contrast, the Vmax profile does not show substantial changes across the pH range

737193