2.3.1.17: aspartate N-acetyltransferase

This is an abbreviated version!
For detailed information about aspartate N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyltransferase, aspartate, ANAT, aspartate acetyltransferase, aspartate N-acetyltransferase, aspartic acetylase, L-aspartate N-acetyltransferase, NAT, NAT8L

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.17 aspartate N-acetyltransferase

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Results	in table
1	Activating Compound
16	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
3	Crystallization (Commentary)
45	Disease/ Diagnostics
2	General Information
2	IC50 Value
55	Inhibitors
24	Ki Value [mM]
30	KM Value [mM]
11	Localization
10	Metals/Ions
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
17	Organism
2	Pathway
3	pH Optimum
3	pH Range
15	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
17	Reference
25	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
24	Substrates and Products (Substrate)
4	Subunits
19	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

KM Value

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KM Value on EC 2.3.1.17 - aspartate N-acetyltransferase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.92

2,3-diaminosuccinate

Homo sapiens

Q8N9F0

pH 7.4, temperature not specified in the publication

737193

0.36

3-methyl-L-aspartate

Homo sapiens

Q8N9F0

pH 7.4, temperature not specified in the publication

737193

0.001 - 1.06

acetyl-CoA

13 entries

5

glutamate

Mus musculus

-

-

702144

0.09 - 3.37

L-aspartate

11 entries

8.6

L-glutamate

Homo sapiens

Q8N9F0

pH 7.4, temperature not specified in the publication

737193

additional information

additional information

3 entries

-

0.001

acetyl-CoA

Homo sapiens

Q8N9F0

wild-type, pH 7.1, 30°C

718791

0.0031

acetyl-CoA

Homo sapiens

Q8N9F0

pH 7.4, temperature not specified in the publication

737193

0.009

acetyl-CoA

Mus musculus

-

in presence of 0.5 mM CHAPS

702144

0.012

acetyl-CoA

Homo sapiens

Q8N9F0

mutant P142A, pH 7.1, 30°C

718791

0.013

acetyl-CoA

Mus musculus

-

in presence of 1 mM CHAPS

702144

0.017

acetyl-CoA

Homo sapiens

Q8N9F0

mutant S132F/R133F, pH 7.1, 30°C

718791

0.019

acetyl-CoA

Homo sapiens

Q8N9F0

mutant R133A, pH 7.1, 30°C

718791

0.058

acetyl-CoA

Rattus norvegicus

-

pH 7.1, 37°C

659757

0.082

acetyl-CoA

Homo sapiens

Q8N9F0

mutant R81A, pH 7.1, 30°C

718791

0.127

acetyl-CoA

Homo sapiens

Q8N9F0

mutant E101A, pH 7.1, 30°C

718791

0.14

acetyl-CoA

Homo sapiens

Q8N9F0

mutant R220K, pH 7.1, 30°C

718791

0.4

acetyl-CoA

Homo sapiens

Q8N9F0

mutant R220A, pH 7.1, 30°C

718791

0.8 - 1.06

acetyl-CoA

Rattus norvegicus

-

pH 7.0, 37°C, slightly varying Km depending on source organelle

658360

0.09

L-aspartate

Mus musculus

-

-

702144

0.09

L-aspartate

Homo sapiens

Q8N9F0

wild-type, pH 7.1, 30°C

718791

0.095

L-aspartate

Homo sapiens

Q8N9F0

mutant P142A, pH 7.1, 30°C

718791

0.128

L-aspartate

Homo sapiens

Q8N9F0

mutant S132F/R133F, pH 7.1, 30°C

718791

0.16

L-aspartate

Homo sapiens

Q8N9F0

pH 7.4, temperature not specified in the publication

737193

0.166 - 0.174

L-aspartate

Rattus norvegicus

-

pH 7.0, 37°C, slightly varying Km depending on source organelle

658360

0.2

L-aspartate

Homo sapiens

Q8N9F0

mutant R81A, pH 7.1, 30°C

718791

0.434

L-aspartate

Homo sapiens

Q8N9F0

mutant E101A, pH 7.1, 30°C

718791

0.58

L-aspartate

Rattus norvegicus

-

pH 7.1, 37°C

659757

1.61

L-aspartate

Homo sapiens

Q8N9F0

mutant R220K, pH 7.1, 30°C

718791

3.37

L-aspartate

Homo sapiens

Q8N9F0

mutant R220A, pH 7.1, 30°C

718791

additional information

additional information

Rattus norvegicus

-

Km value for acetyl-CoA

486456

-

additional information

additional information

Homo sapiens

Q8N9F0

Michaelis-Menten kinetics

737193

-

additional information

additional information

Homo sapiens

-

Michaelis-Menten kinetics

737193

-