2.3.1.135: phosphatidylcholine-retinol O-acyltransferase

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For detailed information about phosphatidylcholine-retinol O-acyltransferase, go to the full flat file.

Reaction

Synonyms

11-cis-acyl-CoA:retinol O-acyltransferase, acyltransferase, lecithin-retinol, EC 5.2.1.3, lecithin retinol acyl transferase, lecithin retinol acyltransferase, lecithin-retinol acyltransferase, lecithin/retinol acyltransferase, lecithin: retinol acyltransferase, lecithin:retinol acyl transferase, lecithin:retinol acyltransferase, LRAT, More, retinyl ester synthase, retinyl-ester synthase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.135 phosphatidylcholine-retinol O-acyltransferase

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Results	in table
19	Activating Compound
16	AA Sequence
7	Application
1	CAS Registry Number
26	Cloned(Commentary)
1	Crystallization (Commentary)
89	Disease/ Diagnostics
2	Expression
22	General Information
4	General Stability
28	Inhibitors
1	kcat/KM [mM/s]
39	KM Value [mM]
25	Localization
4	Metals/Ions
9	Molecular Weight [Da]
54	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
136	Organism
4	Pathway
4	PDB ID
12	pH Optimum
2	pH Range
1	pH Stability
36	Protein Variants
20	Purification (Commentary)
4	Reaction
1	Reaction Type
76	Reference
139	Source Tissue
21	Specific Activity [micromol/min/mg]
3	Storage Stability
165	Substrates and Products (Substrate)
19	Subunits
86	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Expression

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Expression on EC 2.3.1.135 - phosphatidylcholine-retinol O-acyltransferase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

expression of LRAT and RPE65 can be modulated by retinoids

Homo sapiens

-

715720

interleukin-1 can potently downregulate mRNA and protein levels of LRAT and act as injury signal resulting in mobilization of retinyl esters in primary rat hepatic stellate cells. Secreted factors from Kupffer cells are able to suppress LRAT expression in hepatic stellate cells, which is neutralized by interleukin-1 receptor antagonist. The regulation is likely at transcriptional level. Interleukin-1 fails to downregulate recombinant LRAT protein expressed in the cells by adenovirus, while transcription of endogenous LRAT is promptly decreased. Interleukin-1 is a key mediator to down-regulate LRAT in liver injury

Rattus norvegicus

-

720839