2.3.1.135: phosphatidylcholine-retinol O-acyltransferase

This is an abbreviated version!
For detailed information about phosphatidylcholine-retinol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.135

2.3.1.135

retinoids

retinal

all-trans-retinyl

opsin

11-cis-retinol

isomerohydrolase

amaurosis

leber

s-opsins

11-cis-retinoids

medicine

crbp-i

diagnostics

analysis

Reaction

retinol-[cellular-retinol-binding-protein]

retinyl-ester-[cellular-retinol-binding-protein]

Synonyms

11-cis-acyl-CoA:retinol O-acyltransferase, acyltransferase, lecithin-retinol, EC 5.2.1.3, lecithin retinol acyl transferase, lecithin retinol acyltransferase, lecithin-retinol acyltransferase, lecithin/retinol acyltransferase, lecithin: retinol acyltransferase, lecithin:retinol acyl transferase, lecithin:retinol acyltransferase, LRAT, More, retinyl ester synthase, retinyl-ester synthase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.135 phosphatidylcholine-retinol O-acyltransferase

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Results	in table
19	Activating Compound
16	AA Sequence
7	Application
1	CAS Registry Number
26	Cloned(Commentary)
1	Crystallization (Commentary)
89	Disease/ Diagnostics
2	Expression
22	General Information
4	General Stability
28	Inhibitors
1	kcat/KM [mM/s]
39	KM Value [mM]
25	Localization
4	Metals/Ions
9	Molecular Weight [Da]
54	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
136	Organism
4	Pathway
4	PDB ID
12	pH Optimum
2	pH Range
1	pH Stability
36	Protein Variants
20	Purification (Commentary)
4	Reaction
1	Reaction Type
76	Reference
139	Source Tissue
21	Specific Activity [micromol/min/mg]
3	Storage Stability
165	Substrates and Products (Substrate)
19	Subunits
86	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.3.1.135 - phosphatidylcholine-retinol O-acyltransferase

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13-demethyl-13,14-dihydro-all-trans-retinyl trifluoroacetate

Bos taurus

competitive with respect to dipalmitoylphosphocholine, uncompetitive with respect to all-trans-retinol; reversible inhibitor

638611

all-trans-retinyl-alpha-bromoacetate

2 entries

all-trans-retinylbromoacetate

Bos taurus

658662

Apo-cellular-retinol-binding protein

Rattus norvegicus

638612

apo-CRBP-I

Mus musculus

i.e. apo-[cellular retinol-binding protein I], no inhibition by apo-CRBP-III

674449

fenretinide

Mus musculus

used clinically to presumably lower blood retinol-binding protein levels and thus decrease circulating retinol, targets the functional coupling of STRA6 and LRAT to increase cellular vitamin A uptake in peripheral tissues

720030

N-Boc-L-biocytinyl-11-aminoundecan chloromethylketone

Bos taurus

0.002 mM, 45% inhibition; irreversible inhibitor; time dependent inhibition

638617

N-ethylmaleimide

3 entries

p-chloromercuribenzoic acid

Rattus norvegicus

0.005 mM, complete inhibition of retinol-(cellular-retinol-binding-protein)type II esterification

638609

palmitoyl-CoA

Bos taurus

658662

phenylmethylsulfonyl fluoride

3 entries

retinyl bromoacetate

Homo sapiens

78% reduction of enzyme activity

658661

retinylamine

2 entries

additional information

9 entries