Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.3.1.135: phosphatidylcholine-retinol O-acyltransferase

This is an abbreviated version!
For detailed information about phosphatidylcholine-retinol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.135

Reaction

phosphatidylcholine
+
retinol-[cellular-retinol-binding-protein]
=
2-acylglycerophosphocholine
+
retinyl-ester-[cellular-retinol-binding-protein]

Synonyms

11-cis-acyl-CoA:retinol O-acyltransferase, acyltransferase, lecithin-retinol, EC 5.2.1.3, lecithin retinol acyl transferase, lecithin retinol acyltransferase, lecithin-retinol acyltransferase, lecithin/retinol acyltransferase, lecithin: retinol acyltransferase, lecithin:retinol acyl transferase, lecithin:retinol acyltransferase, LRAT, More, retinyl ester synthase, retinyl-ester synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.135 phosphatidylcholine-retinol O-acyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.3.1.135 - phosphatidylcholine-retinol O-acyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
lecithin + 11-cis-retinol-[cellular retinol-binding protein]
2-acylglycerophosphocholine + 11-cis-retinyl ester-[cellular retinol-binding protein]
show the reaction diagram
-
-
-
-
r
lecithin + all-trans-retinol-[cellular retinol-binding protein]
2-acylglycerophosphocholine + all-trans-retinyl ester-[cellular retinol-binding protein]
show the reaction diagram
-
-
-
-
r
lecithin + retinol-[cellular retinol-binding protein III]
2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
show the reaction diagram
lecithin + retinol-[cellular retinol-binding protein]
2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein]
show the reaction diagram
palmitoyl-CoA + 11-cis-retinol-[cellular retinol-binding protein]
CoA + 11-cis-retinyl palmitate-[cellular retinol-binding protein]
show the reaction diagram
-
esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
-
-
?
palmitoyl-CoA + all-trans-retinol-[cellular retinol-binding protein]
CoA + all-trans-retinyl palmitate-[cellular retinol-binding protein]
show the reaction diagram
-
esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells
-
-
?
phosphatidylcholine + 11-cis-retinol
2-acylglycerophosphocholine + 11-cis-retinyl acyl ester
show the reaction diagram
essential for generation of the precursor for 11-cis-retinal, the visual chromophore in the eye
-
-
?
phosphatidylcholine + 11-cis-retinol-[cellular-retinol-binding-protein]
2-acylglycerophosphocholine + 11-cis-retinyl-ester-[cellular-retinol-binding-protein]
show the reaction diagram
-
trans-esterification reaction is reversible, however in the presence of the isomerase, all-trans-retinyl esters are converted to 11-cis-retinol which is enzymatically oxidized to 11-cis-retinal, the chromophore of vision. Both all-trans-retinol and 11-cis-retinol are substrates for LRAT esterification, although all-transretinol is the preferred substrate.
-
-
r
phosphatidylcholine + 11-cis-retinoll-[cellular-retinol-binding-protein]
2-acylglycerophosphocholine + 11-cis-retinyl-ester-[cellular-retinol-binding-protein]
show the reaction diagram
-
trans-esterification reaction is reversible, however in the presence of the isomerase, all-trans-retinyl esters are converted to 11-cis-retinol which is enzymatically oxidized to 11-cis-retinal, the chromophore of vision. Both all-trans-retinol and 11-cis-retinol are substrates for LRAT esterification, although all-transretinol is the preferred substrate.
-
-
r
phosphatidylcholine + all-trans-retinol
2-acylglycerophosphocholine + all-trans-retinyl acyl ester
show the reaction diagram
enzyme is involved in vitamin A storage and mobilization
-
-
r
phosphatidylcholine + all-trans-retinol
2-acylglycerophosphocholine + all-trans-retinyl ester
show the reaction diagram
-
LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A
-
-
?
phosphatidylcholine + all-trans-retinol
2-acylglycerophosphocholine + retinyl ester
show the reaction diagram
-
LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A
-
-
?
phosphatidylcholine + all-trans-retinol
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
show the reaction diagram
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein]
2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
show the reaction diagram
phosphatidylcholine + all-trans-retinylamine
2-acylglycerophosphocholine + all-trans-retinyl acylamide
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + retinol-[cellular-retinol-binding-protein]
2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
show the reaction diagram
phosphatidylcholine + retinylamine
2-acylglycerophosphocholine + fatty acid N-retinylamide
show the reaction diagram
-
-
-
-
?
additional information
?
-