2.1.1.79: cyclopropane-fatty-acyl-phospholipid synthase
This is an abbreviated version!
For detailed information about cyclopropane-fatty-acyl-phospholipid synthase, go to the full flat file.
Reaction
Synonyms
C17:cyclopropane synthase, Cfa, CFA synthase, cfaB, CFAS, CPS, CPS1, CPS2, CPS3, cyclopropane fatty acid synthase, cyclopropane fatty acid synthetase, cyclopropane fatty acyl synthase, cyclopropane synthase, cyclopropane-fatty-acyl-phospholipid synthase, HP0416, SfCPA-FAS, synthetase, cyclopropane fatty acid, unsaturated-phospholipid methyltransferase
ECTree
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KI Value
KI Value on EC 2.1.1.79 - cyclopropane-fatty-acyl-phospholipid synthase
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0.0011 - 0.0014
(12aS,12bS)-7-fluoro-2,3,5,12,12a,12b-hexahydro-1H,4H-11-oxa-3a,9b-diazabenzo[a]naphtho[2,1,8-cde]azulene
0.0011
(12aS,12bS)-7-fluoro-2,3,5,12,12a,12b-hexahydro-1H,4H-11-oxa-3a,9b-diazabenzo[a]naphtho[2,1,8-cde]azulene
-
inhibits CAFS in a mixed-type fashion with respect to phospholipids
0.0014
(12aS,12bS)-7-fluoro-2,3,5,12,12a,12b-hexahydro-1H,4H-11-oxa-3a,9b-diazabenzo[a]naphtho[2,1,8-cde]azulene
-
inhibits the CFAS non-competitively with respect to AdoMet
0.006
-
apparent inhibition constant when the phospholipids are the variable substrates. Noncompetitive inhibitor with respect to both substrates
0.016
5'-S-[2-(decylamino)ethyl]-5'-thioadenosine
-
apparent inhibition constant when S-adenosyl-L-methionine is the variable substrates. Noncompetitive inhibitor with respect to both substrates
0.00026
dioctylamine
-
uncompetitive inhibitor with respect to S-adenosyl-L-methionine
0.0005
sinefungin
-
competitive inhibitor with respect to S-adenosyl-L-methionine
0.0072
sinefungin
-
non-competitive inhibitor with respect to the phospholipids