2.1.1.49: amine N-methyltransferase

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For detailed information about amine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.49

2.1.1.49

n-methylation

smoke

cyp2a6

urine

n-methyltransferases

flavin-containing

monooxygenase

udp-glucuronosyltransferases

smoking

Reaction

Synonyms

aromatic alkylamine-N-methyltransferase, arylamine N-methyltransferase, EC 2.1.1.81, methyltransferase, tryptamine, nicotine N-methyltransferase, tryptamine methyltransferase, tryptamine N-methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.49 amine N-methyltransferase

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Results	in table
1	Activating Compound
25	AA Sequence
1	CAS Registry Number
4	Cofactor
2	Inhibitors
2	Ki Value [mM]
19	KM Value [mM]
4	Localization
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
1	PDB ID
4	pH Optimum
2	pH Range
2	pH Stability
3	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
15	Source Tissue
14	Specific Activity [micromol/min/mg]
3	Storage Stability
34	Substrates and Products (Substrate)
4	Subunits
7	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
14	Turnover Number [1/s]

KM Value

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KM Value on EC 2.1.1.49 - amine N-methyltransferase

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0.01 - 2

7,8-dichloro-1,2,3,4-tetrahydroisoquinoline

2 entries

7.6 - 7.8

aniline

2 entries

6.25

beta-phenylethylamine

Rattus norvegicus

5-methyltetrahydrofolate as methyl donor

441353

0.24 - 0.3

desmethylimipramine

2 entries

0.2 - 5.1

imidazole

2 entries

1.5 - 3.2

pyrazole

2 entries

0.015

S-adenosyl-L-methionine

Oryctolagus cuniculus

1 mM tryptamine as methyl acceptor, pH 8.5

441354

0.12 - 35.6

tryptamine

7 entries