2.1.1.49: amine N-methyltransferase

This is an abbreviated version!
For detailed information about amine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.49

2.1.1.49

n-methylation

smoke

cyp2a6

urine

n-methyltransferases

flavin-containing

monooxygenase

udp-glucuronosyltransferases

smoking

Reaction

Synonyms

aromatic alkylamine-N-methyltransferase, arylamine N-methyltransferase, EC 2.1.1.81, methyltransferase, tryptamine, nicotine N-methyltransferase, tryptamine methyltransferase, tryptamine N-methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.49 amine N-methyltransferase

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Results	in table
1	Activating Compound
25	AA Sequence
1	CAS Registry Number
4	Cofactor
2	Inhibitors
2	Ki Value [mM]
19	KM Value [mM]
4	Localization
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
1	PDB ID
4	pH Optimum
2	pH Range
2	pH Stability
3	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
15	Source Tissue
14	Specific Activity [micromol/min/mg]
3	Storage Stability
34	Substrates and Products (Substrate)
4	Subunits
7	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
14	Turnover Number [1/s]

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Reference on EC 2.1.1.49 - amine N-methyltransferase

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441352

Crooks, P.A.; Godin, C.S.; Nwosu, C.G.; Ansher, S.S.; Jakoby, W.B.

Reevaluation of the products of tryptamine catalyzed by rabbit liver N-methyltransferases

Biochem. Pharmacol.

1600-1603

1986

Oryctolagus cuniculus, Oryctolagus cuniculus New Zealand

3707620

441353

Hsu, L.L.; Mandell, A.J.

Multiple N-methyltransferases for aromatic alkylamines in brain

Life Sci.

847-858

1973

Rattus norvegicus

4766261

441354

Ansher, S.S.; Jakoby, W.B.

Amine N-methyltransferases from rabbit liver

J. Biol. Chem.

261

3996-4001

1986

Oryctolagus cuniculus, Oryctolagus cuniculus New Zealand

3949799

441355

Bahnmaier, A.H.; Woesle, B.; Thomas, H.

Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline and salsolidine by amine N-methyltransferase A from bovine liver

Chirality

160-165

1999

Bos taurus

9951405

441356

Kim, Y.H.; Joo, I.

Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligation

Exp. Mol. Med.

23-28

2001

Rattus norvegicus

11322482