2.1.1.251: methylated-thiol-coenzyme M methyltransferase

This is an abbreviated version!
For detailed information about methylated-thiol-coenzyme M methyltransferase, go to the full flat file.

Reaction

Synonyms

480-kDa CoM methylase, CoM methylase, DMS:CoM methyltransferase, methylthiol:coenzyme M methyltransferase, methylthiol:CoM methyltransferase, methyltransferase II, MMPA:CoM methyltransferase, MtsA

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.251 methylated-thiol-coenzyme M methyltransferase

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Results	in table
3	Activating Compound
20	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	Cofactor
13	General Information
1	Inhibitors
5	KM Value [mM]
3	Metals/Ions
5	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
10	Organism
5	Pathway
2	pH Optimum
2	Purification (Commentary)
4	Reaction
6	Reference
1	Renatured (Commentary)
6	Source Tissue
1	Specific Activity [micromol/min/mg]
32	Substrates and Products (Substrate)
1	Subunits
25	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.1.1.251 - methylated-thiol-coenzyme M methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

3-methylmercapto-1-propanol + coenzyme M

methyl-CoM + 3-mercapto-1-propanol

Methanosarcina barkeri

-

-

717563

-

-

?

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylated-thiol-specific corrinoid protein]

4 entries

dimethylsulfide + coenzyme M

methyl-CoM + methanethiol

7 entries

methanethiol + a [Co(I) methylated-thiol-specific corrinoid protein]

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide

4 entries

methanethiol + coenzyme M

methyl-CoM + hydrogen sulfide

2 entries

methylmercaptopropionate + coenzyme M

methyl-CoM + mercaptopropionate

4 entries

additional information

?

-

5 entries

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylated-thiol-specific corrinoid protein]

Methanosarcina barkeri

-

-

717563, 717763

-

-

?

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylated-thiol-specific corrinoid protein]

Methanosarcina barkeri

Q48924

-

717716

-

-

?

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylated-thiol-specific corrinoid protein]

Methanosarcina barkeri Fusaro / DSM 804

-

-

717563

-

-

?

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylated-thiol-specific corrinoid protein]

Methanosarcina barkeri Fusaro, DSM 804

-

-

717563

-

-

?

dimethylsulfide + coenzyme M

methyl-CoM + methanethiol

Methanosarcina barkeri

-

-

717563, 717763

-

-

?

dimethylsulfide + coenzyme M

methyl-CoM + methanethiol

Methanosarcina barkeri

-

-

727732

-

-

r

dimethylsulfide + coenzyme M

methyl-CoM + methanethiol

Methanosarcina barkeri

-

the enzyme functions as a CoM methylase during methanogenesis from dimethylsulfide or methylmercaptopropionate

727732

-

-

?

dimethylsulfide + coenzyme M

methyl-CoM + methanethiol

Methanosarcina barkeri DSM 800

-

-

727732

-

-

r

dimethylsulfide + coenzyme M

methyl-CoM + methanethiol

Methanosarcina barkeri DSM 800

-

the enzyme functions as a CoM methylase during methanogenesis from dimethylsulfide or methylmercaptopropionate

727732

-

-

?

dimethylsulfide + coenzyme M

methyl-CoM + methanethiol

Methanosarcina barkeri Fusaro / DSM 804

-

-

717563

-

-

?

dimethylsulfide + coenzyme M

methyl-CoM + methanethiol

Methanosarcina barkeri Fusaro, DSM 804

-

-

717563

-

-

?

methanethiol + a [Co(I) methylated-thiol-specific corrinoid protein]

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide

Methanosarcina barkeri

-

-

717563, 717763

-

-

?

methanethiol + a [Co(I) methylated-thiol-specific corrinoid protein]

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide

Methanosarcina barkeri

Q48924

-

717716

-

-

?

methanethiol + a [Co(I) methylated-thiol-specific corrinoid protein]

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide

Methanosarcina barkeri Fusaro / DSM 804

-

-

717563

-

-

?

methanethiol + a [Co(I) methylated-thiol-specific corrinoid protein]

a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide

Methanosarcina barkeri Fusaro, DSM 804

-

-

717563

-

-

?

methanethiol + coenzyme M

methyl-CoM + hydrogen sulfide

Methanosarcina barkeri

-

-

717563, 717763

-

-

?

methanethiol + coenzyme M

methyl-CoM + hydrogen sulfide

Methanosarcina barkeri

Q48924

-

717716

-

-

?

methylmercaptopropionate + coenzyme M

methyl-CoM + mercaptopropionate

Methanosarcina barkeri

-

-

717563, 727732

-

-

r

methylmercaptopropionate + coenzyme M

methyl-CoM + mercaptopropionate

Methanosarcina barkeri

-

the enzyme functions as a CoM methylase during methanogenesis from dimethylsulfide or methylmercaptopropionate

727732

-

-

?

methylmercaptopropionate + coenzyme M

methyl-CoM + mercaptopropionate

Methanosarcina barkeri DSM 800

-

-

727732

-

-

r

methylmercaptopropionate + coenzyme M

methyl-CoM + mercaptopropionate

Methanosarcina barkeri DSM 800

-

the enzyme functions as a CoM methylase during methanogenesis from dimethylsulfide or methylmercaptopropionate

727732

-

-

?

additional information

?

-

Methanosarcina barkeri

-

MtsA acts both to demethylate dimethylsulfide and to methylate CoM using non-protein-bound cobalamin as an intermediate methyl carrier, dependence of the rate of the MtsA-catalyzed methylcobalamin:CoM methyl transfer reaction on methylcobalamin, overview. The subunit carries out both CoM methylation and DMS demethylation and can account for both corrinoid-dependent methyltransferase activities of the methylthiol:CoM methyltransferase. A model for the native methylthiol:coenzyme M methyltransferase in which MtsA mediates the methylation of corrinoid bound to MtsB with dimethylsulfide and subsequently demethylates MtsB-bound corrinoid with coenzyme M, overview

717763

-

-

?

additional information

?

-

Methanosarcina barkeri

Q48924

the 480-kDa protein is not methylated by methyltetrahydrosarcinapterin or demethylated by homocysteine. The alpha subunit, not the beta subunit, methylates the thiol of CoM

717716

-

-

?

additional information

?

-

Methanosarcina barkeri

-

the methylthiol:CoM methyltransferase reaction is initiated only with the enzyme-bound corrinoid in the methylated state. CoM can demethylate, and dimethylsulfide and methylmercaptoproionate can remethylate, the corrinoid cofactor

717563

-

-

?

additional information

?

-

Methanosarcina barkeri Fusaro / DSM 804

-

the methylthiol:CoM methyltransferase reaction is initiated only with the enzyme-bound corrinoid in the methylated state. CoM can demethylate, and dimethylsulfide and methylmercaptoproionate can remethylate, the corrinoid cofactor

717563

-

-

?

additional information

?

-

Methanosarcina barkeri Fusaro, DSM 804

-

the methylthiol:CoM methyltransferase reaction is initiated only with the enzyme-bound corrinoid in the methylated state. CoM can demethylate, and dimethylsulfide and methylmercaptoproionate can remethylate, the corrinoid cofactor

717563

-

-

?