2.1.1.247: [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase

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For detailed information about [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase, go to the full flat file.

Reaction

a [methyl-Co(III) methylamine-specific corrinoid protein]

a [Co(I) methylamine-specific corrinoid protein]

Synonyms

corrinoid:coenzyme M methyltransferase, methylated MtmC protein:CoM methyltransferase, methylated [methylamine-specific corrinoid protein]:coenzymeM methyltransferase, methylcobamide:coenzyme M methyltransferase, methylcobamide:CoM methyltransferase, methylcorrinoid:Coenzyme M methyltransferase, methylcorrinoid:CoM methyltransferase, methyltransferase 2, methyltransferase II, MMA-specific methyltransferase, MMA:CoM methyl transferase, MM_1070, MT2, MT2-A, MT2-M, mtaA, mtbA, TMA-specific methyltransferase, TMA:CoM methyl transferase, TMA:CoM methyltransferase, trimethylamine:coenzyme M methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase

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Results	in table
3	Activating Compound
33	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
2	Expression
12	General Information
3	IC50 Value
4	Inhibitors
6	KM Value [mM]
4	Metals/Ions
2	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
17	Organism
5	Pathway
4	PDB ID
5	pH Optimum
2	Purification (Commentary)
2	Reaction
15	Reference
9	Source Tissue
4	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
2	Subunits
48	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

General Information

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General Information on EC 2.1.1.247 - [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase

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evolution

2 entries

malfunction

Methanosarcina barkeri

immunosorptive depletion of MT2 isozymes from cell-free extracts, extracts of methanol-grown cells depleted of MT2-M lose entirely the ability to carry out conversion of methanol to 2-(methylthio)ethanesulfonate, i.e. methyl-CoM. Methanol:CoM methyl transfer activity is completely restored by addition of purified MT2-M, but no activity is recovered by addition of MT2-A. In contrast, the activity of trimethylamine-grown cell extracts to convert monomethylamine and dimethylamine to methyl-CoM is lost almost entirely by immunosorptive removal of MT2-A. Addition of purified MT2-A but not MT2-M, to the MT2-A-depleted extract fully reconstitutes methyl-CoM formation from both mono- and dimethylamine

717754

metabolism

6 entries

additional information

3 entries