2.1.1.230: 23S rRNA (adenosine1067-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (adenosine1067-2'-O)-methyltransferase, go to the full flat file.
Reaction
Synonyms
EC 2.1.1.66, NHR, NHR protein, nosiheptide resistance methyltransferase, nosiheptide-resistance methyltransferase, thiostrepton resistance methyltransferase, thiostrepton-resistance methylase, thiostrepton-resistance methyltransferase, TSR
ECTree
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Inhibitors
Inhibitors on EC 2.1.1.230 - 23S rRNA (adenosine1067-2'-O)-methyltransferase
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Protein L11
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binding of either thiostrepton or protein L11 inhibits methylation
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S-Adenosyl-D-homocysteine
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competitivewith respect to S-adenosyl-L-methionine
Thiostrepton
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binding of either thiostrepton or protein L11 inhibits methylation
stabilizing the RNA tertiary structure, as in RNA mutant U1061A, decreases Tsr binding affinity and catalytic activity independent of RNA structural changes
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additional information
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stabilizing the RNA tertiary structure, as in RNA mutant U1061A, decreases Tsr binding affinity and catalytic activity independent of RNA structural changes
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