2.1.1.220: tRNA (adenine58-N1)-methyltransferase

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For detailed information about tRNA (adenine58-N1)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.220

2.1.1.220

trnaimet

1-methyladenosine

nucleoside

mtases

two-subunit

thermus

exosome

polyadenylation

adomet

t-loop

polya

s-adenosylmethionine

n1-methylation

heterotetramer

homotetrameric

methionyl-trna

high-copy-number

eubacteria

methyltransferases

s-adenosyl-l-homocysteine

two-component

s-adenosyl-l-methionine-dependent

l-shaped

tpsic

trna-binding

hypomodified

drug development

Reaction

Synonyms

EC 2.1.1.36, Gcd10p, Gcd10p-Gcd14p, Gcd10pyGcd14p complex, Gcd14p, m1A58 MTase, m1A58 tRNA methyl-transferase, m1A58 tRNA methyltransferase, m1A58-methyltransferase, m1A58MTase, Rv2118c, Rv2118p, Trm6, TRM6-TRM61 holoenzyme, Trm61A, Trm61B, TRm61p, TRm6p, TrmI, tRNA (m1A58) methyltransferase, tRNA (m1A58) MTase, tRNA m(1)A58 methyltransferase, tRNA m1A58 methyltransferase, two component m1A58 tRNA methyl-transferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.220 tRNA (adenine58-N1)-methyltransferase

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Results	in table
10024	AA Sequence
1	Application
8	Cloned(Commentary)
17	Cofactor
15	Crystallization (Commentary)
9	Disease/ Diagnostics
51	General Information
2	Inhibitors
5	KM Value [mM]
6	Localization
6	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
32	Organism
1	Pathway
15	PDB ID
6	pH Optimum
11	Protein Variants
8	Purification (Commentary)
4	Reaction
30	Reference
6	Source Tissue
45	Substrates and Products (Substrate)
31	Subunits
74	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

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Application on EC 2.1.1.220 - tRNA (adenine58-N1)-methyltransferase

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drug development

Homo sapiens

Q96FX7

the enzyme crystal structures serve as templates for design of inhibitors that can be used to test tRNA m1A58 MTase's impact on retroviral priming and transcription

736642