2.1.1.220: tRNA (adenine58-N1)-methyltransferase

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For detailed information about tRNA (adenine58-N1)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.220

2.1.1.220

trnaimet

1-methyladenosine

nucleoside

mtases

two-subunit

thermus

exosome

polyadenylation

adomet

t-loop

polya

s-adenosylmethionine

n1-methylation

heterotetramer

homotetrameric

methionyl-trna

high-copy-number

eubacteria

methyltransferases

s-adenosyl-l-homocysteine

two-component

s-adenosyl-l-methionine-dependent

l-shaped

tpsic

trna-binding

hypomodified

drug development

Reaction

Synonyms

EC 2.1.1.36, Gcd10p, Gcd10p-Gcd14p, Gcd10pyGcd14p complex, Gcd14p, m1A58 MTase, m1A58 tRNA methyl-transferase, m1A58 tRNA methyltransferase, m1A58-methyltransferase, m1A58MTase, Rv2118c, Rv2118p, Trm6, TRM6-TRM61 holoenzyme, Trm61A, Trm61B, TRm61p, TRm6p, TrmI, tRNA (m1A58) methyltransferase, tRNA (m1A58) MTase, tRNA m(1)A58 methyltransferase, tRNA m1A58 methyltransferase, two component m1A58 tRNA methyl-transferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.220 tRNA (adenine58-N1)-methyltransferase

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Results	in table
10024	AA Sequence
1	Application
8	Cloned(Commentary)
17	Cofactor
15	Crystallization (Commentary)
9	Disease/ Diagnostics
51	General Information
2	Inhibitors
5	KM Value [mM]
6	Localization
6	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
32	Organism
1	Pathway
15	PDB ID
6	pH Optimum
11	Protein Variants
8	Purification (Commentary)
4	Reaction
30	Reference
6	Source Tissue
45	Substrates and Products (Substrate)
31	Subunits
74	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

Disease

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Disease on EC 2.1.1.220 - tRNA (adenine58-N1)-methyltransferase

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Carcinoma

[Comparative study of the tRNA-methylases of normal and tumor tissues. II. Positional specificity of renal and carcinoma RA methylases]

618346

Tuberculosis

Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures.

12682365

Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv.

11554794

Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase.

14960715