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2.1.1.203: tRNA (cytosine34-C5)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (cytosine34-C5)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.203

Reaction

S-adenosyl-L-methionine
+
cytosine34 in tRNA precursor
=
S-adenosyl-L-homocysteine
 +
5-methylcytosine34 in tRNA precursor

Synonyms

5-methylcytosine RNA methyltransferase, cytosine-5 RNA methyltransferase, cytosine-5 tRNA methyltransferase, DnmA, EC 2.1.1.29, hTrm4, M5C RNA methyltransferase, NOP2/Sun domain family member 2, NSUN2, NSUN3, NSUN3 methylase, PMT1, RCMT, RNA:m5C methyltransferase, SAKI, substrate of AIM-1/Aurora kinase B

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.203 tRNA (cytosine34-C5)-methyltransferase

Cloned

Cloned on EC 2.1.1.203 - tRNA (cytosine34-C5)-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of the human Trm4 (hTrm4) cDNA in yeast partially complements the lack of the endogenous Trm4p enzyme
expression of wild-type and mutant enzymes in HCC1954 cells and in COS7 cells
-
gene NSun2, recombinant expression of wild-type and mutant enzymes
recombinant expression of His-tagged NSun2 in Escherichia coli
-
transient expression of C-terminally Flag-tagged NSUN3 in HeLa cells, immunohistochemic analysis shows that NSUN3 predominantly localized in mitochondria