2.1.1.203: tRNA (cytosine34-C5)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (cytosine34-C5)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.203

2.1.1.203

5-methylcytosine

anticodon

homocysteine

wobble

ualcan

5-formylcytosine

biallelic

omnibus

shrinkage

hyperhomocysteinemia

encephalomyopathy

nsun2-mediated

epitranscriptome

early-onset

medicine

pharmacology

Reaction

Synonyms

5-methylcytosine RNA methyltransferase, cytosine-5 RNA methyltransferase, cytosine-5 tRNA methyltransferase, DnmA, EC 2.1.1.29, hTrm4, M5C RNA methyltransferase, NOP2/Sun domain family member 2, NSUN2, NSUN3, NSUN3 methylase, PMT1, RCMT, RNA:m5C methyltransferase, SAKI, substrate of AIM-1/Aurora kinase B

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.203 tRNA (cytosine34-C5)-methyltransferase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
2	Activating Compound
1744	AA Sequence
2	Application
5	Cloned(Commentary)
8	Cofactor
17	Disease/ Diagnostics
1	Expression
29	General Information
9	Localization
1	Metals/Ions
1	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
17	Organism
1	Pathway
2	pH Optimum
1	Posttranslational Modification
12	Protein Variants
1	Purification (Commentary)
2	Reaction
15	Reference
13	Source Tissue
22	Substrates and Products (Substrate)
1	Subunits
29	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Reference

top print

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Reference on EC 2.1.1.203 - tRNA (cytosine34-C5)-methyltransferase

Please use the Reference Search for a specific query.

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

710135

Brzezicha, B.; Schmidt, M.; Makalowska, I.; Jarmolowski, A.; Pienkowska, J.; Szweykowska-Kulinska, Z.

Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu(CAA)

Nucleic Acids Res.

6034-6043

2006

Homo sapiens (Q08J23), Homo sapiens

17071714

718539

Khan, M.A.; Rafiq, M.A.; Noor, A.; Hussain, S.; Flores, J.V.; Rupp, V.; Vincent, A.K.; Malli, R.; Ali, G.; Khan, F.S.; Ishak, G.E.; Doherty, D.; Weksberg, R.; Ayub, M.; Windpassinger, C.; Ibrahim, S.; Frye, M.; Ansar, M.; Vincent, J.B.

Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability

Am. J. Hum. Genet.

856-863

2012

Homo sapiens, Mus musculus

22541562

734682

Hussain, S.; Tuorto, F.; Menon, S.; Blanco, S.; Cox, C.; Flores, J.V.; Watt, S.; Kudo, N.R.; Lyko, F.; Frye, M.

The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation

Mol. Cell. Biol.

1561-1570

2013

Mus musculus

23401851

735680

Moon, H.J.; Redman, K.L.

Trm4 and Nsun2 RNA:m5C methyltransferases form metabolite-dependent, covalent adducts with previously methylated RNA

Biochemistry

7132-7144

2014

Mammalia

25375641

736798

Yuan, S.; Tang, H.; Xing, J.; Fan, X.; Cai, X.; Li, Q.; Han, P.; Luo, Y.; Zhang, Z.; Jiang, B.; Dou, Y.; Gorospe, M.; Wang, W.

Methylation by NSun2 represses the levels and function of microRNA 125b

Mol. Cell. Biol.

3630-3641

2014

Homo sapiens

25047833

737060

Okamoto, M.; Fujiwara, M.; Hori, M.; Okada, K.; Yazama, F.; Konishi, H.; Xiao, Y.; Qi, G.; Shimamoto, F.; Ota, T.; Temme, A.; Tatsuka, M.

tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells

PLoS Genet.

e1004639

2014

Homo sapiens

25233213

756399

Genenncher, B.; Durdevic, Z.; Hanna, K.; Zinkl, D.; Mobin, M.B.; Senturk, N.; Da Silva, B.; Legrand, C.; Carre, C.; Lyko, F.; Schaefer, M.

Mutations in cytosine-5 tRNA methyltransferases impact mobile element expression and genome stability at specific DNA repeats

Cell Rep.

1861-1874

2018

Drosophila melanogaster (Q9W4M9)

29444437

756866

Bohnsack, K.; Hoebartner, C.; Bohnsack, M.

Eukaryotic 5-methylcytosine (M5C) RNA methyltransferases mechanisms, cellular functions, and links to disease

Genes (Basel)

102

2019

Saccharomyces cerevisiae (Q9H649), Homo sapiens (Q9H649)

30704115

757733

Nakano, S.; Suzuki, T.; Kawarada, L.; Iwata, H.; Asano, K.; Suzuki, T.

NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNAMet

Nat. Chem. Biol.

546-551

2016

Homo sapiens (Q9H649), Homo sapiens

27214402

757827

Mueller, M.; Hartmann, M.; Schuster, I.; Bender, S.; Thuering, K.L.; Helm, M.; Katze, J.R.; Nellen, W.; Lyko, F.; Ehrenhofer-Murray, A.E.

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

Nucleic Acids Res.

10952-10962

2015

Schizosaccharomyces pombe (P40999), Dictyostelium discoideum (Q54JH6), Schizosaccharomyces pombe 972 (P40999)

26424849

758103

Gkatza, N.A.; Castro, C.; Harvey, R.F.; Heiss, M.; Popis, M.C.; Blanco, S.; Borneloev, S.; Sajini, A.A.; Gleeson, J.G.; Griffin, J.L.; West, J.A.; Kellner, S.; Willis, A.E.; Dietmann, S.; Frye, M.

Cytosine-5 RNA methylation links protein synthesis to cell metabolism

PLoS Biol.

e3000297

2019

Homo sapiens (Q08J23)

31199786