2.1.1.178: 16S rRNA (cytosine1407-C5)-methyltransferase
This is an abbreviated version!
For detailed information about 16S rRNA (cytosine1407-C5)-methyltransferase, go to the full flat file.
Reaction
Synonyms
16S rRNA methyltransferase, housekeeping methyltransferase RsmF, RNA m5C methyltransferase YebU, RsmF, RsmF housekeeping methyltransferase, YebU
ECTree
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General Information
General Information on EC 2.1.1.178 - 16S rRNA (cytosine1407-C5)-methyltransferase
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malfunction
metabolism
physiological function
inactivation of the yebU gene leads to loss of methylation at C1407 in 16S rRNA. yebU knockout strains display slower growth and reduced fitness in competition with wild-type cells (at 37°C and 42°C)
malfunction
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DELTArsmF null mutant bacteria have a decreased susceptibility to aminoglycosides, including 4,6- and 4,5-deoxystreptamine aminoglycosides
malfunction
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DELTArsmF null mutant bacteria have a decreased susceptibility to aminoglycosides, including 4,6- and 4,5-deoxystreptamine aminoglycosides
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two methyltransferases, RsmB and RsmF, are responsible for all four 5-methylcytidine modifications in 16S rRNA of Thermus thermophilus, overview. RsmB produces m5C967, while RsmF methylates C1400, C1404, and C1407 in a 30S subunit substrate, but only C1400 and C1404 when naked 16S rRNA is the substrate. C1400 and C1404 are sufficiently buried in the mature ribosome structure so require extensive unfolding of the rRNA to be accessible to RsmF
metabolism
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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two methyltransferases, RsmB and RsmF, are responsible for all four 5-methylcytidine modifications in 16S rRNA of Thermus thermophilus, overview. RsmB produces m5C967, while RsmF methylates C1400, C1404, and C1407 in a 30S subunit substrate, but only C1400 and C1404 when naked 16S rRNA is the substrate. C1400 and C1404 are sufficiently buried in the mature ribosome structure so require extensive unfolding of the rRNA to be accessible to RsmF
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the housekeeping methylation at C1407 is involved in intrinsic aminoglycoside susceptibility in Escherichia coli
physiological function
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the housekeeping methylation at C1407 is involved in intrinsic aminoglycoside susceptibility in Escherichia coli
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