2.1.1.117: (S)-scoulerine 9-O-methyltransferase

This is an abbreviated version!
For detailed information about (S)-scoulerine 9-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

(S)-Adenosyl-L-methionine:(S)-scoularine 9-O-methyltransferase, (S)-scoulerine 9-O-methyltransferase, Methyltransferase, (S)-scoularine 9-, Methyltransferase, (S)-scoularine 9- (Coptis japonica clone pCJSMT), scoulerine 9-O-methyltransferase, scoulerine 9-OMT, scoulerine-9-O-methyltransferase, scoulerine/reticuline O-methyltransferase, SMT, SOMT, SOMT1

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.117 (S)-scoulerine 9-O-methyltransferase

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Results	in table
18	AA Sequence
2	Application
2	CAS Registry Number
4	Cloned(Commentary)
1	General Information
16	Inhibitors
10	kcat/KM [mM/s]
15	KM Value [mM]
1	Localization
1	Metals/Ions
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
14	Organism
7	Pathway
8	PDB ID
3	pH Optimum
2	pH Range
1	pI Value
2	Purification (Commentary)
1	Reaction
1	Reaction Type
14	Reference
9	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
28	Substrates and Products (Substrate)
3	Subunits
15	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
10	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.117 - (S)-scoulerine 9-O-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-homocysteine + (S)-tetrahydropalmatrubine

S-adenosyl-L-homocysteine + (S)-tetrahydropalmatine

Stephania intermedia

A0A5P9PAM0

-

756272

-

-

?

S-Adenosyl-L-methionine + (R,S)-2,3,9,10-tetrahydroxytetrahydroprotoberberine

?

Berberis wilsoniae

-

methylated at 50% of the rate of (S)-scoulerine

15196

-

-

?

S-Adenosyl-L-methionine + (S)-3,9-dihydroxy-2,10-dimethoxytetrahydroprotoberberine

?

Berberis wilsoniae

-

methylated at 4% of the rate of (S)-scoulerine

15196

-

-

?

S-adenosyl-L-methionine + (S)-norreticuline

S-adenosyl-L-homocysteine + norcodamine + norlaudanine

Eschscholzia californica subsp. californica

A0A224ALZ8

-

757982

-

-

?

S-adenosyl-L-methionine + (S)-reticuline

S-adenosyl-L-homocysteine + codamine + laudanine

Eschscholzia californica subsp. californica

A0A224ALZ8

-

757982

-

-

?

S-Adenosyl-L-methionine + (S)-scoulerine

?

3 entries

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

8 entries

S-adenosyl-L-methionine + (S)-scoulerine

S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine + 2-O-methylscoulerine + tetrahydropalmatine

Eschscholzia californica subsp. californica

A0A224ALZ8

-

757982

-

-

?

S-adenosyl-L-methionine + (S)-tetrahydrocolumbamine

S-adenosyl-L-homocysteine + (S)-tetrahydropalmatine

Stephania intermedia

A0A5P9PAM0

-

756272

-

-

?

S-Adenosyl-L-methionine + 6-O-methylnorlaudanosoline

?

Coptis japonica

-

8% of the activity relative to (S)-scoulerine

15193

-

-

?

S-Adenosyl-L-methionine + norlaudanosoline

?

Coptis japonica

-

2% of the activity relative to (S)-scoulerine

15193

-

-

?

S-Adenosyl-L-methionine + norreticuline

?

Coptis japonica

-

9% of the activity relative to (S)-scoulerine

15193

-

-

?

additional information

?

-

2 entries

S-Adenosyl-L-methionine + (S)-scoulerine

?

Berberis stolonifera

-

-

15195

-

-

?

S-Adenosyl-L-methionine + (S)-scoulerine

?

Berberis wilsoniae

-

central role in orotoberberine biosynthesis

15196

-

-

?

S-Adenosyl-L-methionine + (S)-scoulerine

?

Coptis japonica

-

the enzyme is responsible for a late step in the biosynthesis of berberine

15192, 15194, 15195

-

-

?

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Berberis stolonifera

-

-

15195

-

-

?

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Berberis wilsoniae

-

-

15196

-

15196

?

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Coptis chinensis

E0W6R9

-

733669

-

-

ir

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Coptis japonica

-

-

15192

-

15192

?

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Coptis japonica

-

-

15193, 15194, 15195, 720655

-

-

?

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Coptis teeta

A0A2Z5FRS0

-

756838

-

-

?

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Papaver somniferum

-

-

727532

-

-

?

S-Adenosyl-L-methionine + (S)-scoulerine

S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine

Stephania intermedia

A0A5P9PAM0

-

756272

-

-

?

additional information

?

-

Eschscholzia californica subsp. californica

A0A224ALZ8

enzyme is a scoulerine-9-O-methyltransferase for the biosynthesis of chelerythrine in California poppy, it produces 7-O-methylated, 3'-O-methylated and dual O-methylated products from reticuline and norreticuline, and 9-O-methylated tetrahydrocolumbamine, 2-O-methylscoulerine and tetrahydropalmatine from scoulerine

757982

-

-

-

additional information

?

-

Stephania intermedia

A0A5P9PAM0

enzyme catalyzes O-methylation at C-9 and C-2, and O-methylation events occur first at C-9 and then at C-2

756272

-

-

-