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2.1.1.114: polyprenyldihydroxybenzoate methyltransferase

This is an abbreviated version!
For detailed information about polyprenyldihydroxybenzoate methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.114

Reaction

S-adenosyl-L-methionine
+
3,4-dihydroxy-5-all-trans-polyprenylbenzoate
=
S-adenosyl-L-homocysteine
+
3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate

Synonyms

3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, AtCOQ3, COQ-3, COQ3, Coq3 O-methyltransferase, Coq3p, DHHB methyltransferase, DHHB-MTase, dihydroxyhexaprenylbenzoate methyltransferase, UbiG, ubiquinone biosynthesis O-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.114 polyprenyldihydroxybenzoate methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.114 - polyprenyldihydroxybenzoate methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 3,4-dihydroxy-5-((2E,6E)-farnesyl)benzoate
S-adenosyl-L-homocysteine + 5-((2E,6E)-farnesyl)-4-hydroxy-3-methoxybenzoate
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-farnesylbenzoate
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate
S-adenosyl-L-homocysteine + 5-(2E,6E)-farnesyl-4-hydroxy-3-methoxybenzoate
show the reaction diagram
in vitro assay
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate
S-adenosyl-L-homocysteine + 5-all-trans-hexaprenyl-4-hydroxy-3-methoxybenzoate
show the reaction diagram
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
show the reaction diagram
S-adenosyl-L-methionine + 3,4-dihydroxy-5-hexaprenylbenzoate
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-hexaprenylbenzoate
show the reaction diagram
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6, 1. the methylation of 3,4-dihydroxy-5-hexaprenylbenzoate and 2. the methylation of 3-demethylubiquinol-6 (this reaction is classified as EC 2.1.1.64)
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-octaprenylbenzoate
S-adenosyl-L-homocysteine + 4-hydroxy-3-methoxy-5-octaprenylbenzoate
show the reaction diagram
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8, 1. the methylation of 3,4-dihydroxy-5-octaprenylbenzoate and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64)
-
-
?
S-adenosyl-L-methionine + 5-all-trans-decaprenyl-3,4-dihydroxybenzoate
S-adenosyl-L-homocysteine + 5-all-trans-decaprenyl-4-hydroxy-3-methoxybenzoate
show the reaction diagram
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 5-all-trans-decaprenyl-3,4-dihydroxybenzoate and 2. the methylation of 3-demethylubiquinol-10 (this reaction is classified as EC 2.1.1.64)
-
-
?
additional information
?
-
wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol
-
-
?