2.1.1.114: polyprenyldihydroxybenzoate methyltransferase

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For detailed information about polyprenyldihydroxybenzoate methyltransferase, go to the full flat file.

Reaction

Synonyms

3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, AtCOQ3, COQ-3, COQ3, Coq3 O-methyltransferase, Coq3p, DHHB methyltransferase, DHHB-MTase, dihydroxyhexaprenylbenzoate methyltransferase, UbiG, ubiquinone biosynthesis O-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.114 polyprenyldihydroxybenzoate methyltransferase

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Results	in table
2348	AA Sequence
1	Application
2	CAS Registry Number
8	Cloned(Commentary)
1	Crystallization (Commentary)
6	General Information
4	Localization
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
25	Organism
9	Pathway
2	pH Optimum
2	Purification (Commentary)
1	Reaction
1	Reaction Type
12	Reference
1	Source Tissue
13	Substrates and Products (Substrate)
3	Subunits
21	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.114 - polyprenyldihydroxybenzoate methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:3,4-dihydroxy-5-all-trans-polyprenylbenzoate 3-O-methyltransferase

This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast [3]. The enzymes from yeast and rat also catalyse the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively [2] (this activity is classified as EC 2.1.1.64, 3-demethylubiquinol 3-O-methyltransferase).