2.1.1.114: polyprenyldihydroxybenzoate methyltransferase
This is an abbreviated version!
For detailed information about polyprenyldihydroxybenzoate methyltransferase, go to the full flat file.
Reaction
Synonyms
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, AtCOQ3, COQ-3, COQ3, Coq3 O-methyltransferase, Coq3p, DHHB methyltransferase, DHHB-MTase, dihydroxyhexaprenylbenzoate methyltransferase, UbiG, ubiquinone biosynthesis O-methyltransferase
ECTree
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Cloned
Cloned on EC 2.1.1.114 - polyprenyldihydroxybenzoate methyltransferase
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AtCOQ3 is able to restore the respiration ability and ubiquinone synthesis of the coq3 deletion mutant of Saccharomyces cerevisiae
expressed in Escherichia coli BL21(DE3) cells
rat COQ3 gene restores O-methyltransferase activity in coq3 null mutant yeast
the rescue of the yeast coq3 mutant by the rat homologue suggests that yeast and rat synthesize ubiquinone via the same early steps in this pathway
when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast