2.1.1.107: uroporphyrinogen-III C-methyltransferase

This is an abbreviated version!
For detailed information about uroporphyrinogen-III C-methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

adenosylmethionine-uroporphyrinogen III methyltransferase, At5g40850, CobA, CobA/HemD, CysG, HemD-CobA, NirE, S-adenosyl-L-methionine dependent uroporphyrinogen III methylase, S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SAM-dependent uroporphyrinogen III methyltransferase, sirohaem synthase, SUMT, UMT, UPM1, UroM, uroporphyrinogen III C-methyltransferase, uroporphyrinogen III methylase, uroporphyrinogen III methyltransferase, uroporphyrinogen III methyltransferase/synthase, uroporphyrinogen III synthase/methyltransferase, uroporphyrinogen methyltransferase,

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.107 uroporphyrinogen-III C-methyltransferase

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Results	in table
37557	AA Sequence
2	Application
1	CAS Registry Number
21	Cloned(Commentary)
5	Cofactor
4	Crystallization (Commentary)
1	Expression
8	General Information
1	General Stability
7	Inhibitors
1	Ki Value [mM]
8	KM Value [mM]
4	Localization
1	Metals/Ions
27	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
33	Organism
6	Pathway
50	PDB ID
3	pH Optimum
33	Protein Variants
12	Purification (Commentary)
3	Reaction
1	Reaction Type
32	Reference
3	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
55	Substrates and Products (Substrate)
17	Subunits
40	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.1.1.107 - uroporphyrinogen-III C-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase

This enzyme catalyses two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III. The second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76, precorrin-2 dehydrogenase) and the third step involves the chelation of Fe2+ to sirohydrochlorin to form siroheme (EC 4.99.1.4, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction. Also involved in the biosynthesis of cobalamin.