adenosylmethionine-uroporphyrinogen III methyltransferase, At5g40850, CobA, CobA/HemD, CysG, HemD-CobA, NirE, S-adenosyl-L-methionine dependent uroporphyrinogen III methylase, S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SAM-dependent uroporphyrinogen III methyltransferase, sirohaem synthase, SUMT, UMT, UPM1, UroM, uroporphyrinogen III C-methyltransferase, uroporphyrinogen III methylase, uroporphyrinogen III methyltransferase, uroporphyrinogen III methyltransferase/synthase, uroporphyrinogen III synthase/methyltransferase, uroporphyrinogen methyltransferase,
the enzyme is important in the heme d1 biosynthesis, the essential prosthetic group of the dissimilatory nitrite reductase cytochrome cd1 requiring the methylation of the tetrapyrrole precursor uroporphyrinogen III at positions C-2 and C-7, pathway overview
the enzyme is involved in the tetrapyrrole biosynthesis. Uroporphyrinogen III represents the first branch point in the pathway, where the action of enzymes such as HemE, F (N) and G results in the formation of protoporphyrin IX, a precursor of modified tetrapyrroles such as haem and chlorophyll. Alternatively, uroporphyrinogen III can undergo a S-adenosylmethionine-dependent transmethylation positions 2 and 7, by CysG, Met1p or CobA depending on the organism, to generate precorrin-2, a highly unstable yellow dipyrrocorphin, overview
overexpression of UPM1 signals higher nitrite reductase (NII) and sulfite reductase gene and gene product expression. Increased NII expression regulates and enhances the transcript and protein abundance of nitrate reductase. Due to higher N and S assimilation in these plants, total protein content increases. Consequently, chlorophyll biosynthesis increases and upregulates photosynthetic electron transport and carbon assimilation. In the antisense plants, the transcript abundance, and protein content of nitrite reductase (NII) and sulfite reductase decrease, resulting in reduced total protein and chlorophyll content