2.1.1.10: homocysteine S-methyltransferase

This is an abbreviated version!
For detailed information about homocysteine S-methyltransferase, go to the full flat file.

Reaction

Synonyms

adenosylmethionine transmethylase, adenosylmethionine:homocysteine methyltransferase, AtHMT-1, AtHMT-2, AtHMT-3, BHMT, BHMT-2, F775_07039, HMT, HMT1, homocysteine methylase, homocysteine methyltransferase, homocysteine methyltransferase Mht1, homocysteine methyltransferase Sam4, homocysteine transmethylase, L-homocysteine S-methyltransferase, methylmethionine:homocysteine methyltransferase, S-adenosyl-L-methionine:L-homocysteine methyltransferase, S-adenosylmethionine homocysteine transmethylase, S-adenosylmethionine-homocysteine transmethylase, S-adenosylmethionine:homocysteine methyltransferase, S-methylmethionine homocysteine transmethylase, S-methylmethionine: homocysteine methyltransferase, S-methylmethionine: homocysteine S-methyltransferase, SMM:homocysteine S-methyltransferase, YagD, YagD protein

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.10 homocysteine S-methyltransferase

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Results	in table
8	Activating Compound
2746	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
4	Disease/ Diagnostics
1	Expression
3	General Information
1	General Stability
15	Inhibitors
15	KM Value [mM]
4	Localization
8	Metals/Ions
10	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
32	Organism
7	Pathway
4	PDB ID
6	pH Optimum
1	pH Range
1	pI Value
4	Protein Variants
3	Purification (Commentary)
2	Reaction
1	Reaction Type
31	Reference
17	Source Tissue
18	Specific Activity [micromol/min/mg]
69	Substrates and Products (Substrate)
7	Subunits
30	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Turnover Number [1/s]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 2.1.1.10 - homocysteine S-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(R,S)-S-adenosyl-L-methionine + L-homocysteine

L-methionine + S-adenosyl-L-homocysteine

2 entries

(S,S)-S-adenosyl-L-methionine + L-homocysteine

L-methionine + S-adenosyl-L-homocysteine

Saccharomyces cerevisiae

-

higher affinity for R,S form

719868

-

-

?

betaine + L-homocysteine

dimethylglycine + L-methionine

Rattus norvegicus

O09171

-

756095

-

-

?

S-adenosyl-D-methionine + L-homocysteine

?

4 entries

S-adenosyl-L-ethionine + L-homocysteine

S-adenosyl-L-homocysteine + L-ethionine

Saccharomyces cerevisiae

-

-

441385

-

441385

?

S-adenosyl-L-methionine + D-homocysteine

?

Saccharomyces cerevisiae

-

-

441385

-

-

?

S-adenosyl-L-methionine + DL-cysteine

S-adenosyl-L-homocysteine + S-methyl-DL-cysteine

Brassica oleracea

A4ZGQ8

-

676384

-

-

?

S-adenosyl-L-methionine + DL-homocysteine

L-methionine + S-adenosyl-L-homocysteine

Brassica oleracea

A4ZGQ8

-

676384

-

-

?

S-adenosyl-L-methionine + DL-selenocysteine

S-adenosyl-L-homocysteine + Se-methyl-DL-selenocysteine

Brassica oleracea

A4ZGQ8

-

676384

-

-

?

S-adenosyl-L-methionine + L-cysteine

S-adenosyl-L-homocysteine + S-methyl-L-cysteine

Brassica oleracea

A4ZGQ8

-

676384

-

-

?

S-adenosyl-L-methionine + L-homocysteine

?

Homo sapiens

-

low activity

687808

-

-

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

28 entries

S-adenosyl-L-methionine + L-homocysteine thiolactone

?

Saccharomyces cerevisiae

-

-

441385

-

-

?

S-adenosyl-L-methionine + L-selenocysteine

S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine

Brassica oleracea

A4ZGQ8

-

676384

-

-

?

S-methyl-L-methionine + L-cysteine

?

Arabidopsis thaliana

Q9M1W4, Q9SDL7

-

441387

-

-

?

S-methyl-L-methionine + L-homocysteine

2 L-methionine

7 entries

S-methyl-L-methionine + L-homocysteine

?

9 entries

S-methyl-L-methionine + L-homocysteine

L-methionine

2 entries

S-methyl-L-methionine + selenohomocysteine

?

Escherichia coli

Q47690

-

692820

-

-

?

additional information

?

-

7 entries

(R,S)-S-adenosyl-L-methionine + L-homocysteine

L-methionine + S-adenosyl-L-homocysteine

Escherichia coli

-

-

733302

(R,S)-S-adenosyl-L-methionine is preferred over (S,S)-S-adenosyl-L-methionine

-

?

(R,S)-S-adenosyl-L-methionine + L-homocysteine

L-methionine + S-adenosyl-L-homocysteine

Saccharomyces cerevisiae

-

-

719868

-

-

?

S-adenosyl-D-methionine + L-homocysteine

?

Klebsiella aerogenes

-

-

441383

-

-

?

S-adenosyl-D-methionine + L-homocysteine

?

Klebsiella aerogenes NRRL 199

-

-

441383

-

-

?

S-adenosyl-D-methionine + L-homocysteine

?

Saccharomyces cerevisiae

-

-

441383

-

-

?

S-adenosyl-D-methionine + L-homocysteine

?

Saccharomyces cerevisiae

-

low activity

441386

-

-

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Arabidopsis thaliana

Q9M1W4, Q9SDL7

the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo

441387

-

-

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Arabidopsis thaliana

Q9M1W4, Q9SDL7

the Km-value for S-adenosyl-L-methionine is higher than for S-methyl-L-methionine and the Vmax value is lower

441387

-

-

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Arabidopsis thaliana

Q8LAX0

the Km-value for S-adenosyl-L-methionine is higher than for S-methyl-L-methionine and the Vmax value is lower

694665

-

-

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Canavalia ensiformis

-

enzymic preference of the pro-(R)-methyl group to the extent of 94% or more

693336

-

-

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Cyberlindnera jadinii

-

-

441383

-

441383

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Equus caballus

-

-

441383

-

441383

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli

-

-

441382

-

441382

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli

-

-

441383

-

441383

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli

-

-

441384

-

441384

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli

Q47690

-

692948

-

-

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli

-

biosynthesis of methionine

441382

-

441382

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli

-

biosynthesis of methionine

441383

-

441383

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli

-

biosynthesis of methionine

441384

-

441384

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli Texas M

-

-

441382

-

441382

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Escherichia coli Texas M

-

biosynthesis of methionine

441382

-

441382

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Klebsiella aerogenes

-

-

441383

-

441383

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Klebsiella aerogenes

-

-

441384

-

441384

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Klebsiella aerogenes

-

-

441385

-

441385

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Klebsiella aerogenes NRRL 199

-

-

441383

-

441383

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Lemna aequinoctialis

-

-

485143

-

-

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Rattus norvegicus

-

-

441384

-

441384

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Rattus norvegicus

-

-

441385

-

441385

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Saccharomyces cerevisiae

-

-

441383

-

441383

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Saccharomyces cerevisiae

-

-

441384

-

441384

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Saccharomyces cerevisiae

-

-

441385

-

441385

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Saccharomyces cerevisiae

-

-

441386

-

441386

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Saccharomyces cerevisiae

-

-

441388

-

441388

?

S-adenosyl-L-methionine + L-homocysteine

S-adenosyl-L-homocysteine + L-methionine

Saccharomyces cerevisiae

-

-

441389

-

441389

?

S-methyl-L-methionine + L-homocysteine

2 L-methionine

Aegilops tauschii

M8C0H7

-

756423

-

-

?

S-methyl-L-methionine + L-homocysteine

2 L-methionine

Arabidopsis thaliana

Q9M1W4, Q9SDL7

-

441387

-

-

?

S-methyl-L-methionine + L-homocysteine

2 L-methionine

Arabidopsis thaliana

Q8LAX0

-

694665

-

-

?

S-methyl-L-methionine + L-homocysteine

2 L-methionine

Arabidopsis thaliana

Q8LAX0

synthesis of L-methionine from homocysteine

694665

-

-

?

S-methyl-L-methionine + L-homocysteine

2 L-methionine

Arabidopsis thaliana

Q9M1W4, Q9SDL7

the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo

441387

-

-

?

S-methyl-L-methionine + L-homocysteine

2 L-methionine

Escherichia coli

-

-

733302

-

-

?

S-methyl-L-methionine + L-homocysteine

2 L-methionine

Escherichia coli

Q47690

-

692948

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Escherichia coli

-

-

441383

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Escherichia coli

-

S-methyl-L-methionine more effective methyl donor than S-adenosyl-L-methionine

441384

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Homo sapiens

-

high homology to betaine-homocysteine methyltransferase (BHMT, EC 2.1.1.5), betaine is not a substrate for BHMT-2 but high activity with S-methyl-L-methionine

687808

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Klebsiella aerogenes

-

-

441383

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Klebsiella aerogenes

-

S-methyl-L-methionine more effective methyl donor than S-adenosyl-L-methionine

441384

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Klebsiella aerogenes NRRL 199

-

-

441383

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Rattus norvegicus

-

S-methyl-L-methionine more effective methyl donor than S-adenosyl-L-methionine

441384

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Saccharomyces cerevisiae

-

-

441383

-

-

?

S-methyl-L-methionine + L-homocysteine

?

Saccharomyces cerevisiae

-

S-methyl-L-methionine more effective methyl donor than S-adenosyl-L-methionine

441384

-

-

?

S-methyl-L-methionine + L-homocysteine

L-methionine

Escherichia coli

Q47690

-

692820

-

-

?

S-methyl-L-methionine + L-homocysteine

L-methionine

Escherichia coli

Q47690

metabolism of S-methylmethionine requires a functional YagD protein, since inactivation of the yagD gene abolishes the capacity to grow on S-methylmethionine

692820

-

-

?

additional information

?

-

Arabidopsis thaliana

Q9M1W4

no activity with D-cysteine, L-cysteine, DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate

441387

-

-

?

additional information

?

-

Arabidopsis thaliana

Q9SDL7

no activity with D-cysteine, L-cysteine, DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate

441387

-

-

?

additional information

?

-

Arabidopsis thaliana

Q9M1W4

no activity with DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate

441387

-

-

?

additional information

?

-

Arabidopsis thaliana

Q9SDL7

no activity with DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate

441387

-

-

?

additional information

?

-

Escherichia coli

Q47690

the enzyme also catalyzes the reaction of selenocysteine methyltransferase

692948

-

-

?

additional information

?

-

Escherichia coli

-

the enzyme also catalyzes the reaction of selenocysteine methyltransferase

692948

-

-

?

additional information

?

-

Escherichia coli

-

no substrate: S-ribosyl-L-methionine

733302

-

-

?