1.5.1.6: formyltetrahydrofolate dehydrogenase
This is an abbreviated version!
For detailed information about formyltetrahydrofolate dehydrogenase, go to the full flat file.
Reaction
Synonyms
10-FDH, 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, 10-fTHF dehydrogenase, 10-FTHFDH, ALDH1L1, ALDH1L2, dehydrogenase, formyltetrahydrofolate, FBP-CI, FBP-CI proteins, FDH, folate-binding proteins, cytosol I, More, mtFDH, N10-formyltetrahydrofolate dehydrogenase, proteins, folate-binding, cytosol I
ECTree
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Inhibitors
Inhibitors on EC 1.5.1.6 - formyltetrahydrofolate dehydrogenase
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chymotrypsin
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cleavage between the two domains, inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase and aldehyde dehydrogenase activity
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propanal
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FDH activity decreases with increasing concentrations, competes with 10-formyltetrahydrofolate for NADP+-dependent oxidation
Subtilisin
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cleavage between the two domains, inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase and aldehyde dehydrogenase activity
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tetrahydropteroylhexaglutamate
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1 mol per mol of tetrameric protein, potent product inhibitor: 0.0003 mM, 90% inhibition
tetrahydrofolate
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competitive to 10-formyltetrahydrofolate and non-competitive to NADP+; very strong product inhibition
tetrahydropteroylpolyglutamate
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inhibition increases with increasing length of polyglutamyl chain
tetrahydropteroylpolyglutamate
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inhibition increases with increasing length of polyglutamyl chain; potent product inhibitor
Trypsin
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cleavage between the two domains, inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase and aldehyde dehydrogenase activity
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Trypsin
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tryptic digestion inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase activity
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Trypsin
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20 min, 70% inhibition, rapid but incomplete loss of dehydrogenase activity; tryptic digestion inactivates 10-formyltetrahydrofolate dehydrogenase but not hydrolase activity
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additional information
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not inhibited by the folate analog N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]-benzoyl]-L-glutamate
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additional information
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recombinant FDH is not inhibited by sodium azide
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additional information
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not inhibited by (+)-10-formyltetrahydrofolate, 5-formyltetrahydrofolate, 5-methyltetrahydrofolate, folate, aminopterin, tetrahydroaminopterin
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