1.5.1.6: formyltetrahydrofolate dehydrogenase
This is an abbreviated version!
For detailed information about formyltetrahydrofolate dehydrogenase, go to the full flat file.
Reaction
Synonyms
10-FDH, 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, 10-fTHF dehydrogenase, 10-FTHFDH, ALDH1L1, ALDH1L2, dehydrogenase, formyltetrahydrofolate, FBP-CI, FBP-CI proteins, FDH, folate-binding proteins, cytosol I, More, mtFDH, N10-formyltetrahydrofolate dehydrogenase, proteins, folate-binding, cytosol I
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Source Tissue
Source Tissue on EC 1.5.1.6 - formyltetrahydrofolate dehydrogenase
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additional information
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significantly decreased levels of FDH and its mRNA in 15 tested tumors compared with normal tissues, strong down-regulation of FDH on both the mRNA and protein level in tumors
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activity in human liver is 26% of that in rat liver, reduced amount of enzyme in human liver
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very high concentrations, two livers, 120 g, contain about 360 mg enzyme
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392335, 392336, 392339, 392341, 392342, 392343, 392345, 392346, 392347, 392351, 392352, 392353, 392355, 674389
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activity in human liver is 26% of that in rat liver, reduced amount of enzyme in human liver
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feeding of ethanol decreases hepatic enzyme activity, decrease occurs irrespective of folate status
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much lower levels than in liver, preferentially localized in Müller cells, FDH levels in human retina are higher than in rat retina, folate levels in human retina are 14% of those in rat retina
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much lower levels than in liver, preferentially localized in Müller cells, FDH levels in human retina are higher than in rat retina, folate levels in human retina are 14% of those in rat retina
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FDH expression is highly tissue specific, very low or nondetectable levels of FDH mRNA in placenta, spleen, colon, small intestine, and leukocytes
additional information
cytosolic FDH mRNa is not detectable in cancer cells
additional information
cytosolic FDH mRNa is not detectable in cancer cells
additional information
In contrast to the cytosolic enzyme, mtFDH mRNA and protein are clearly present in cancer cell lines
additional information
In contrast to the cytosolic enzyme, mtFDH mRNA and protein are clearly present in cancer cell lines
additional information
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In contrast to the cytosolic enzyme, mtFDH mRNA and protein are clearly present in cancer cell lines