1.17.7.3: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

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For detailed information about (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin), go to the full flat file.

Reaction

Synonyms

(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating), (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate reductase, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, GcpE, HMBPP synthase, IspG

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.7 With an iron-sulfur protein as acceptor

                1.17.7.3 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

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Results	in table
30750	AA Sequence
1	Cloned(Commentary)
5	Cofactor
5	General Information
1	IC50 Value
14	Inhibitors
1	KM Value [mM]
4	Metals/Ions
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
10	Organism
3	Pathway
1	pH Optimum
1	pH Range
3	Protein Variants
3	Purification (Commentary)
1	Reaction
10	Reference
2	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
2	Subunits
21	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 1.17.7.3 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

2 entries

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced 10-methyl-5-deazaisoalloxazine

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized 10-methyl-5-deazaisoalloxazine

Escherichia coli

P62620

-

639344

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced deazaflavin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized deazaflavin

Escherichia coli

P62620

low activity with photoreduced deazaflavin as an artifactual electron donor

675579

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

7 entries

[(2R,3R)-3-(hydroxymethyl)-3-methyloxiran-2-yl]methyl trihydrogen diphosphate + O2

[(2R,3R)-3-(hydroxymethyl)-3-methyloxiran-2-yl]methyl trihydrogen diphosphate + H2O

Thermus thermophilus

Q72H18

-

744021

-

-

?

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

Escherichia coli

-

-

744689

-

-

?

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

Thermus thermophilus

Q72H18

-

744021

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

Escherichia coli

-

-

745692

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

Escherichia coli

P62620

-

728960, 745426

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

Escherichia coli

P62620

the enzyme is involved in the deoxyxylulose phosphate pathway of isoprenoid biosynthesis

639344

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

Escherichia coli

P62620

the enzyme is involved in the nonmevalonate pathway of isoprenoid biosynthesis

675579, 728960

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

Escherichia coli

P62620

flavodoxin is essential for activity

729725

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

Escherichia coli

P62620

lower apparent activities are found using photoreduced deazaflavin as an artifactual electron donor, whereas dithionite is unable to serve as an artificial electron donor

675579

-

-

?

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin

Escherichia coli CAR005

-

-

745692

-

-

?