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1.17.7.3: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

This is an abbreviated version!
For detailed information about (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin), go to the full flat file.

Word Map on EC 1.17.7.3

Reaction

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate
+
H2O
 +
oxidized flavodoxin
=
2-C-methyl-D-erythritol 2,4-cyclodiphosphate
 +
reduced flavodoxin

Synonyms

(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating), (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate reductase, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, GcpE, HMBPP synthase, IspG

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.7 With an iron-sulfur protein as acceptor
                1.17.7.3 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

Metals Ions

Metals Ions on EC 1.17.7.3 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
iron-sulfur centre
the protein contained 2.4 iron ions and 4.4 sulfide ions per subunit
Mn2+
reactivates EDTA-inactivated enzyme
[4Fe-4S]2+ cluster
the purified protein is inactive. It is activated after reconstitution of its Fe/S cluster
additional information
the enzyme is active in absence of added metal ions