1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive)
This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-insensitive), go to the full flat file.
Word Map on EC 1.17.4.5
-
1.17.4.5
-
anticoagulant
-
coagulation
-
k-dependent
-
carboxylase
-
non-hepatic
-
4-hydroxycoumarins
-
dosing
-
warfarin-resistant
-
vkorc1
-
2,3-epoxide
-
clotting
-
s-warfarin
-
pharmacogenetic
-
dithiothreitol-dependent
-
scottish
-
rodenticide
- 1.17.4.5
-
anticoagulant
-
coagulation
-
k-dependent
- carboxylase
-
non-hepatic
- 4-hydroxycoumarins
-
dosing
-
warfarin-resistant
- vkorc1
- 2,3-epoxide
-
clotting
-
s-warfarin
-
pharmacogenetic
-
dithiothreitol-dependent
-
scottish
-
rodenticide
Reaction
Synonyms
EC 1.1.4.2, non-VKOR, reductase, vitamin K epoxide (warfarin-insensitive), vitamin K 2,3 epoxide reductase, vitamin K epoxide reductase, vitamin K epoxide reductase (warfarin-insensitive), vitamin K epoxide reductase-like1, vitamin KO reductase, VKOR, VKOR-like1, VKORC1L1, VKORL1
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 1.17.4.5 - vitamin-K-epoxide reductase (warfarin-insensitive)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
-
-
?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
i.e. vitamin K 2,3-epoxide
i.e. 3-hydroxy-2,3-dihydro-vitamin K
?
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
-
-
-
?
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
-
-
?
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
-
-
-
?
?
-
the enzyme, driven by the reducing agent DTT, reduces both vitamin K 2,3-epoxide and vitamin K to the activated hydroquinone form
-
-
?
additional information
?
-
-
the enzyme, driven by the reducing agent DTT, reduces both vitamin K 2,3-epoxide and vitamin K to the activated hydroquinone form
-
-
?