1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-insensitive), go to the full flat file.

Reaction

Synonyms

EC 1.1.4.2, non-VKOR, reductase, vitamin K epoxide (warfarin-insensitive), vitamin K 2,3 epoxide reductase, vitamin K epoxide reductase, vitamin K epoxide reductase (warfarin-insensitive), vitamin K epoxide reductase-like1, vitamin KO reductase, VKOR, VKOR-like1, VKORC1L1, VKORL1

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.4 With a disulfide as acceptor

                1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
2	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Cofactor
2	Disease/ Diagnostics
4	General Information
1	General Stability
5	IC50 Value
10	Inhibitors
4	Localization
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
4	Organism
1	pH Optimum
5	Protein Variants
1	Purification (Commentary)
1	Reaction
3	Reaction Type
4	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
6	Substrates and Products (Substrate)
1	Subunits
12	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

General Information

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

General Information on EC 1.17.4.5 - vitamin-K-epoxide reductase (warfarin-insensitive)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Homo sapiens

Q8N0U8

VKORL1, EC 1.1.4.2, is more highly conserved among vertebrates than its evolutionary relative VKOR, EC 1.1.4.1. The human paralogous proteins are 42-60% identical

724800

metabolism

Homo sapiens

Q8N0U8

vitamin K cycle, overview

724800

physiological function

Homo sapiens

Q8N0U8

vitamin K dependent oxidative protection is independent of VKOR inhibition by warfarin and GGCX inhibition by 2-chloro-vitamin K1, which indicates that vitamin K plays potential physiological roles outside of the realm of carboxylation. The hVKORL1 turnover rate for vitamin K 2,3-epoxide reductase activity is significantly slower than for hVKOR, EC 1.1.4.1. the physiological role for VKORL1 reduction of vitamin K 2,3-epoxide is minimal

724800

additional information

Homo sapiens

-

conserved loop cysteines in VKOR are not required for active site regeneration after each cycle of oxidation. Missense mutations identified in the VKOR coding region, especially hotspot mutation at position 139, lead to a VKOR molecule more resistant to warfarin inhibition, thus requiring higher therapeutic warfarin doses

725845