Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-insensitive), go to the full flat file.

Word Map on EC 1.17.4.5

Reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone
+
oxidized dithiothreitol
=
2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone
+
1,4-dithiothreitol

Synonyms

EC 1.1.4.2, non-VKOR, reductase, vitamin K epoxide (warfarin-insensitive), vitamin K 2,3 epoxide reductase, vitamin K epoxide reductase, vitamin K epoxide reductase (warfarin-insensitive), vitamin K epoxide reductase-like1, vitamin KO reductase, VKOR, VKOR-like1, VKORC1L1, VKORL1

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive)

Reference

Reference on EC 1.17.4.5 - vitamin-K-epoxide reductase (warfarin-insensitive)

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mukharji, I.; Silverman, R.B.
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone
Proc. Natl. Acad. Sci. USA
82
2713-2717
1985
Bos taurus
Manually annotated by BRENDA team
Hodroge, A.; Longin-Sauvageon, C.; Fourel, I.; Benoit, E.; Lattard, V.
Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants
Arch. Biochem. Biophys.
515
14-20
2011
Rattus norvegicus
Manually annotated by BRENDA team
Van Horn, W.D.
Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1
Crit. Rev. Biochem. Mol. Biol.
48
357-372
2013
Homo sapiens (Q8N0U8), Homo sapiens
Manually annotated by BRENDA team
Tie, J.K.; Jin, D.Y.; Tie, K.; Stafford, D.W.
Evaluation of warfarin resistance using TALENs-mediated vitamin K epoxide reductase knockout HEK293 cells
J. Thromb. Haemost.
11
1556-1564
2013
Homo sapiens
Manually annotated by BRENDA team