1.11.1.20: prostamide/prostaglandin F2alpha synthase
This is an abbreviated version!
For detailed information about prostamide/prostaglandin F2alpha synthase, go to the full flat file.
Reaction
Synonyms
PGF prostamide F synthase, PM/PGFS, Pmpgfs, prostaglandin F ethanolamide synthase, prostamide F synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase
ECTree
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General Information
General Information on EC 1.11.1.20 - prostamide/prostaglandin F2alpha synthase
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malfunction
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the elevation of intraocular pressure caused by deletion of the enzyme gene likely results from a diversion of the endoperoxide precursor pathway to provide increased levels of those prostanoids known to raise intraocular pressure, namely prostaglandin D2 and thromboxane A2
physiological function
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prostaglandin ethanolamide, i.e. prostamide, F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide (anandamide) that induces pharmacological actions in ocular tissues. Prostamide/PGF synthase catalyzes the reductions of prostamide H2 to prostamide F2alpha and PGH2 to PGF2alpha, chiefly in the central nervous system
physiological function
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the enzyme serves an important regulatory role in the eye by providing prostaglandin F2alpha and prostamide F2alpha to constrain the influence of those prostanoids that raise intraocular pressure