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1.11.1.20: prostamide/prostaglandin F2alpha synthase

This is an abbreviated version!
For detailed information about prostamide/prostaglandin F2alpha synthase, go to the full flat file.

Reaction

thioredoxin
+
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
=
thioredoxin disulfide
+
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate

Synonyms

PGF prostamide F synthase, PM/PGFS, Pmpgfs, prostaglandin F ethanolamide synthase, prostamide F synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.20 prostamide/prostaglandin F2alpha synthase

KM Value

KM Value on EC 1.11.1.20 - prostamide/prostaglandin F2alpha synthase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0076 - 0.014
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
0.0069 - 0.007
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
0.026
cumene hydroperoxide
0.0069 - 1.6
H2O2
0.0069
prostaglandin H2
in 0.1 M KPB (pH 7.0), at 24°C
0.0076
prostamide H2
in 0.1 M KPB (pH 7.0), at 24°C
0.4
t-butyl hydroperoxide
in 0.1 M KPB (pH 7.0), at 24°C
0.4
tert-butyl hydroperoxide
pH 7.0, 24°C
0.001
thioredoxin
pH 7.0, 24°C