1.1.99.24: hydroxyacid-oxoacid transhydrogenase

This is an abbreviated version!
For detailed information about hydroxyacid-oxoacid transhydrogenase, go to the full flat file.

Reaction

Synonyms

ADHFE1, alcohol dehydrogenase iron containing 1, HOT, hydroxyacid-oxoacid transhydrogenase, iron-dependent alcohol dehydrogenase ADHFe1, transhydrogenase, hydroxy acid-oxo acid

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.24 hydroxyacid-oxoacid transhydrogenase

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Results	in table
1	Activating Compound
3740	AA Sequence
1	Application
1	CAS Registry Number
1	Cloned(Commentary)
6	Cofactor
65	Disease/ Diagnostics
1	Expression
2	General Information
1	General Stability
2	IC50 Value
4	Inhibitors
2	Ki Value [mM]
22	KM Value [mM]
3	Localization
2	Metals/Ions
4	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
196	Organism
5	pH Optimum
1	pI Value
3	Purification (Commentary)
1	Reaction
5	Reaction Type
34	Reference
23	Source Tissue
5	Specific Activity [micromol/min/mg]
39	Substrates and Products (Substrate)
2	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Expression

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Expression on EC 1.1.99.24 - hydroxyacid-oxoacid transhydrogenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

ADHFE1 expression is regulated by DNA methylation. ADHFE1 is frequently downregulated and hypermethylated in various cancer cell lines and tissue samples. High expression of ADHFE1 is positively associated with favorable patient prognosis in breast, colon, and gastric cancers

Homo sapiens

Q8IWW8

763531