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(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
4-hydroxybutanoic acid + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
additional information
?
-
-
D-2-hydroxyglutaric aciduria is not associated to the enzyme activity
-
-
-
(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
3-hydroxybutyrate + 2-oxoglutarate

succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
r
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
radiolabeled substrate 3-hydroxybutyrate, stereospecific reaction
radiolabeled product D-2-hydroxyglutarate
-
r
4-hydroxybutyrate + 2-oxoglutarate

D-2-hydroxyglutarate + succinate semialdehyde
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate

succinic semialdehyde + 2-hydroxyglutarate
-
-
-
r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
-
hydrogen attached to hydroxyl-bearing C of 4-hydroxybutyrate is transferred to ketone-bearing C of 2-oxoglutarate, oxoacid not NAD+ or NADP+ acts as hydrogen acceptor
-
r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
-
hydrogen attached to hydroxyl-bearing C of 4-hydroxybutyrate is transferred to ketone-bearing C of 2-oxoglutarate, oxoacid not NAD+ or NADP+ acts as hydrogen acceptor
-
r
4-hydroxybutyrate + 2-oxoglutarate

succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
recombinant enzyme in HEK-293 cells
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
stereospecific reaction, no activity with L-2-hydroxyglutarate
-
-
r
D-2-hydroxyglutarate + succinic semialdehyde

2-oxoglutarate + 4-hydroxybutyrate
-
-
-
?
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
-
-
-
?
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
-
-
-
?
L-3-hydroxybutyrate + 2-oxoglutarate

acetoacetate + 2-oxoglutarate
-
-
-
?
L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
-
oxidized at 33% the rate of 4-hydroxybutyrate
-
?
L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
-
oxidized at 33% the rate of 4-hydroxybutyrate
-
?
L-3-hydroxybutyrate + succinic semialdehyde

acetoacetate + 4-hydroxybutyrate
-
-
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
62.5% of activity with D-2-hydroxyglutarate
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
62.5% of activity with D-2-hydroxyglutarate
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
r
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
additional information
?
-
-
D-2-hydroxyglutaric aciduria is not associated to the enzyme activity
-
-
-
(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
W4G0G7
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
W4G0G7
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
A0A024TMA3
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
A0A024TMA3
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
F1A5G4
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
T0Q1Z2
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
T0Q1Z2
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
A0A067BRK4
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
A0A067BRK4
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
A0A0L0DHP5
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
A0A0L0DHP5
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate

D-2-hydroxyglutarate + succinate semialdehyde
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate

succinic semialdehyde + D-2-hydroxyglutarate
-
recombinant enzyme in HEK-293 cells
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Kaufman, E.E.; Nelson, T.
An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway
Neurochem. Res.
16
965-974
1991
Rattus norvegicus
brenda
Kaufman, E.E.; Nelson, T.; Fales, H.M.; Levin, D.M.
Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria
J. Biol. Chem.
263
16872-16879
1988
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Kardon, T.; Noel, G.; Vertommen, D.; Van Schaftingen, E.
Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate
FEBS Lett.
580
2347-2350
2006
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Struys, E.A.; Verhoeven, N.M.; Ten Brink, H.J.; Wickenhagen, W.V.; Gibson, K.M.; Jakobs, C.
Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
J. Inherit. Metab. Dis.
28
921-930
2005
Homo sapiens
brenda
Lyon, R.C.; Johnston, S.M.; Panopoulos, A.; Alzeer, S.; McGarvie, G.; Ellis, E.M.
Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1
Chem. Biol. Interact.
178
283-287
2009
Homo sapiens, Homo sapiens (Q8IWW8)
brenda
Gaona-Lopez, C.; Julian-Sanchez, A.; Riveros-Rosas, H.
Diversity and evolutionary analysis of iron-containing (type-III) alcohol dehydrogenases in eukaryotes
PLoS ONE
11
e0166851
2016
Acanthamoeba castellanii (L8HAM2), Acanthamoeba castellanii NEFF (L8HAM2), Acytostelium subglobosum, Acytostelium subglobosum LB1, Aphanomyces astaci (W4G0G7), Aphanomyces astaci APO3 (W4G0G7), Aphanomyces invadans (A0A024TMA3), Aphanomyces invadans NJM9701 (A0A024TMA3), Capsaspora owczarzaki, Capsaspora owczarzaki ATCC 30864, Dictyostelium discoideum, Dictyostelium lacteum (F4PTP3), Dictyostelium purpureum (F1A5G4), Phaeodactylum tricornutum (B7FWP2), Phaeodactylum tricornutum CCAP 1055/1 (B7FWP2), Polysphondylium pallidum, Reticulomyxa filosa (X6NPJ7), Saprolegnia diclina (T0Q1Z2), Saprolegnia diclina VS20 (T0Q1Z2), Saprolegnia parasitica (A0A067BRK4), Saprolegnia parasitica CBS223.65 (A0A067BRK4), Thalassiosira oceanica (K0T042), Thecamonas trahens (A0A0L0DHP5), Thecamonas trahens ATCC 50062 (A0A0L0DHP5)
brenda
Yang, X.; Xie, W.; Li, R.M.; Zhou, X.M.; Wang, S.L.; Wu, Q.J.; Yang, N.N.; Xia, J.X.; Yang, Z.Z.; Guo, L.T.; Liu, Y.T.; Zhang, Y.J.
RNA interference-mediated knockdown of the hydroxyacid-oxoacid transhydrogenase gene decreases thiamethoxam resistance in adults of the whitefly Bemisia tabaci
Sci. Rep.
7
41201
2017
Bemisia tabaci (S5YSM1)
brenda