1.1.1.216: farnesol dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about farnesol dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
dehydrogenase, farnesol (nicotinamide adenine dinucleotide phosphate), More, NAD(P)+-dependent farnesol dehydrogenase, NADP+-dependent farnesol dehydrogenase 1, NADP-farnesol dehydrogenase, SDR-1
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.216 - farnesol dehydrogenase (NADP+)
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REACTION DIAGRAM
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
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preferred substrates
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(2Z,6E)-farnesol + NAD+
(2Z,6E)-farnesal + NADH + H+
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66% of the activity with 2-trans,6-trans-farnesol
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(2Z,6Z)-farnesol + NAD+
(2Z,6Z)-farnesal + NADH + H+
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47% of the activity with 2-trans,6-trans-farnesol
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(2Z,6Z)-farnesol + NADP+
(2Z,6Z)-farnesal + NADPH + H+
enzyme shows highest affinity for farnesol
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(S)-perillyl alcohol + NAD+
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34% of the activity with 2-trans,6-trans-farnesol
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cinnamyl alcohol + NAD+
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35% of the activity with 2-trans,6-trans-farnesol
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nerodilol + NAD+
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36% of the activity with 2-trans,6-trans-farnesol
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trans,trans-farnesol + NADP+
trans,trans-farnesal + NADPH
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preferred substrate
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r
(2E,6E)-farnesal + NADPH + H+
enzyme shows highest affinity for farnesol
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ir
(2E,6E)-farnesol + NADP+
(2E,6E)-farnesal + NADPH + H+
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NADP+ show 22% of the activity with NAD+
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no activity is detected for butanol, ethanol, or glycerol, or for farnesal or farnesoic acid
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additional information
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trans,trans-farnesol is the preferred substrate for the Polygonum minus farnesol dehydrogenase, the geometrical isomers cis,trans-farnesol and cis,cis-farnesol are also oxidized by the enzyme with lower activity. No activity with nerol, p-cumic alcohol, borneol, linalool, menthol, beta-citronellol, 3,7-dihydrolinalool, benzyl alcohol, 2,4-octadien-1-ol, or 2,5-dimethyl-1.5-hexadien-3-ol, tetrahydrogeraniol, tetrahydrolinalool, tetrahydrolavandulol, ethanol, and methanol. Substrate specificity, overview
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additional information
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enzyme is highly specific for trans, trans-farnesol, and NADP+
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additional information
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(2E,6E)-farnesol is the most preferred substrate
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