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Results 1 - 10 of 59 > >>
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76A68C/C188S no specific activity using phenylmalonate as a substrate -, 681486
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76C101S mutant enzymes Cys101Ser, Cys148Ser, Cys171Ser and Cys188Ser. CD spectra indicate that the conformational differences of Cys101Ser and Cys188Ser compared to that of the native enzyme are not significant. Only Cys188Ser shows a drastic decrease in enzyme activity, indicating that Cys188 is located at the active centre 4832
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76C148S mutant enzymes Cys101Ser, Cys148Ser, Cys171Ser and Cys188Ser. CD spectra indicate that the conformational differences of Cys101Ser and Cys188Ser compared to that of the native enzyme are not significant. Only Cys188Ser shows a drastic decrease in enzyme activity, indicating that Cys188 is located at the active centre 4832
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76C171S mutant enzymes Cys101Ser, Cys148Ser, Cys171Ser and Cys188Ser. CD spectra indicate that the conformational differences of Cys101Ser and Cys188Ser compared to that of the native enzyme are not significant. Only Cys188Ser shows a drastic decrease in enzyme activity, indicating that Cys188 is located at the active centre 4832
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76C188S activity with methyl(2-thienyl)malonic acid is 0.7% of wild-type activity, activity with methyl(2-naphthyl)malonic acid is 2.8% of the wild-type activity, with formation of the opposite enantiomer 664586
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76C188S in contrast to the bellshaped pH profile of the wild-type enzyme, the activity of the mutant enzyme C188S retains its full activity from pH 6.0 to pH 11.0 -, 666085
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76C188S mutant enzymes Cys101Ser, Cys148Ser, Cys171Ser and Cys188Ser. CD spectra indicate that the conformational differences of Cys101Ser and Cys188Ser compared to that of the native enzyme are not significant. Only Cys188Ser shows a drastic decrease in enzyme activity, indicating that Cys188 is located at the active centre 4832
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76C188S mutant exhibits decarboxylation activity and gives the opposite enantiomer to that formed by the wild type enzyme -, 681486
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76C188S the activity of the mutant is much lower than that of the native enzyme 714731
Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.76G190A the mutant shows 4.6% relative activity compared to the wild type enzyme 701697
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