EC Number |
Protein Variants |
Reference |
---|
2.7.1.151 | D100A |
isozyme IPK2beta, site-directed mutagenesis, inactive mutant |
662119 |
2.7.1.151 | D144N |
site-directed mutagenesis |
739065 |
2.7.1.151 | D144N/K146A |
site-directed mutagenesis |
739065 |
2.7.1.151 | D98A |
isozyme IPK2alpha, site-directed mutagenesis, inactive mutant |
662119 |
2.7.1.151 | H388A |
site-directed mutagenesis, the mutant shows no Ins(1,4,5)P3 3-kinase activity and reduced Ins(1,3,4,5)P4 6-kinase activity compared to wild-type |
761469 |
2.7.1.151 | K117W |
mutant exhibits nearly normal 6-kinase function but harbors significantly reduced 3-kinase activity. The mutant complements conditional nutritional growth defects observed in ipmk null yeast and suppresses lethality observed in ipmk null flies |
722781 |
2.7.1.151 | K117W/K121W |
mutant exhibits nearly normal 6-kinase function but harbors significantly reduced 3-kinase activity. The mutant complements conditional nutritional growth defects observed in ipmk null yeast and suppresses lethality observed in ipmk null flies |
722781 |
2.7.1.151 | K121W |
although no inositol tetrakisphosphate is present with wild-type IPMK, levels of inositol tetrakisphosphate and inositol hexakisphosphate are equivalent in mutant K121W |
722781 |
2.7.1.151 | K129A/S235A |
catalytically inactive mutant |
739703 |
2.7.1.151 | K146A |
site-directed mutagenesis |
739065 |