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Literature summary for 2.7.1.151 extracted from

  • Wickramasinghe, V.O.; Savill, J.M.; Chavali, S.; Jonsdottir, A.B.; Rajendra, E.; Gruener, T.; Laskey, R.A.; Babu, M.M.; Venkitaraman, A.R.
    Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity (2013), Mol. Cell, 51, 737-750.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D144N site-directed mutagenesis Homo sapiens
D144N/K146A site-directed mutagenesis Homo sapiens
K146A site-directed mutagenesis Homo sapiens
K327Q/K328Q site-directed mutagenesis, generation of an IPMK mutant with inactivated nuclear localization signal, NLS, whose intracellular distribution is unaffected by inhibition of conventional protein import Homo sapiens
additional information overexpression of catalytically inactive IPMK mutants is sufficient to reduce RAD51 foci formation Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Homo sapiens
-
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NFU5 gene impk
-

Source Tissue

Source Tissue Comment Organism Textmining
breast carcinoma cell
-
Homo sapiens
-
CAL-51 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Homo sapiens ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
?

Synonyms

Synonyms Comment Organism
inositol phosphate multikinase
-
Homo sapiens
IPMK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction IPMK depletion or catalytic inactivation selectively decreases RAD51 protein abundance and the nuclear export of RAD51 mRNA, thereby impairing homologous recombination. Depletion or catalytic inactivation of IPMK selectively inhibits the nuclear export of the poly(A)+ mRNAs that encode essential homologous recombination factors such as RAD51, CHK1, or FANCD2, decreasing protein abundance, whereas, in contrast, several genes involved in NHEJ are unaffected. IPMK inactivation inhibits RAD51 recombinase assembly, provokes sensitivity to genotoxic lesions repaired by homologous recombination, and causes structural chromosome aberrations typical of defective homologous recombination. Overexpression of catalytically inactive IPMK mutants is sufficient to reduce RAD51 foci formation Homo sapiens
metabolism the enzyme IPMK is involved in a transcript-selective mRNA export pathway controlled by phosphoinositide turnover that preserves genome integrity in humans Homo sapiens
physiological function inositol phosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity. The transcript-selective nuclear export mechanism affecting certain human transcripts, enriched for functions in genome duplication and repair, is controlled by inositol polyphosphate multikinase, an enzyme catalyzing inositol polyphosphate and phosphoinositide turnover. Function for human IPMK in RAD51 assembly and DNA repair by homologous recombination, overview Homo sapiens