EC Number   |
Protein Variants |
Reference  |
|---|
   2.3.1.250 | H341D |
site-directed mutagenesis, catalytically inactive mutant |
733699 |
| 2.3.1.250 | H341Q |
site-directed mutagenesis, catalytically inactive mutant |
733699 |
| 2.3.1.250 | more |
overexpression of HA-tagged human PORC to confirm the ability of hPORC RNAi constructs to knockdown hPORC expression |
733699 |
| 2.3.1.250 | more |
the catalytically inactive porcupine is able to act as an inhibitor of endogenous porcupine, possibly via direct competition for substrate |
733699 |
| 2.3.1.250 | more |
generation of three different deletion mutants of the enzyme lacking residues 1-34, 1-66, or 1-110 (DELTA34, DELTA66, and DELTA110), the mutants show affeced N-glycosylation of Wingless protein, because the mutant enzymes cannot bind to Wingless, overview |
733769 |
| 2.3.1.250 | more |
rescue of Drosophila melanogaster porc embryos by Mporc RNA injection |
733769 |
| 2.3.1.250 | more |
rescue of Drosophila porc embryos by Mus musculus Mporc RNA injection |
733769 |
| 2.3.1.250 | H341A |
site-directed mutagenesis, catalytic active site mutant, Wnt signaling inactive mutant |
734194 |
| 2.3.1.250 | more |
PORCN is deleted by adenoviral Cre-GFP excision in immortalized MEF cells, PORCN null cells cannot activate WNT3A |
734194 |
| 2.3.1.250 | more |
zinc finger nuclease-mediated PORCN gene deletion in HT1080 cells. Mutation or skipping of PORCN exon 9 creates cells null for PORCN catalytic activity |
734194 |
