EC Number   |
Protein Variants |
Reference |
|---|
    2.1.1.107 | D47N |
binds about a quarter the quantity of S-adenosyl-L-methionine compared with wild-type, reaction product is only poxidised precorrin-1 |
662638 |
| 2.1.1.107 | L49A |
binds about half the quantity of S-adenosyl-L-methionine compared with wild-type, reaction products are oxidised forms of both precorrin-1 and precorrin-2 |
662638 |
| 2.1.1.107 | T130A |
considerably less soluble than wild-type, no binding of S-adenosyl-L-methionine |
662638 |
| 2.1.1.107 | F106A |
considerably less soluble than wild-type, no binding of S-adenosyl-L-methionine, no enzymic activity |
662638 |
| 2.1.1.107 | Y183A |
considerably less soluble than wild-type, no binding of S-adenosyl-L-methionine, no enzyminc activity |
662638 |
| 2.1.1.107 | more |
construction of a nirE transposon mutant, which is not complemented by native cobA encoding the SAM-dependent uroporphyrinogen III methyltransferase involved in cobalamin formation, overview |
703663 |
| 2.1.1.107 | more |
deletion mutants, truncated one deleting the C-terminal extra 52 amino acids actively expressed in Escherichia coli, the mature SUMT fusion mutant or the mature SUMT deleting the N-terminal 36 amino acids including glycine-rich region involved directly in SAM binding expressed as an inclusion body in Escherichia coli |
676956 |
| 2.1.1.107 | D227A |
full activity |
485091 |
| 2.1.1.107 | D303A |
full activity |
485091 |
| 2.1.1.107 | K270I |
full activity |
485091 |
