EC Number |
Protein Variants |
Reference |
---|
2.1.1.107 | D227A |
full activity |
485091 |
2.1.1.107 | D248A |
no transmethylase activity |
485091 |
2.1.1.107 | D303A |
full activity |
485091 |
2.1.1.107 | G224A |
unable to bind S-adenosyl-L-methionine |
485091 |
2.1.1.107 | K270I |
full activity |
485091 |
2.1.1.107 | R298L |
unable to bind S-adenosyl-L-methionine |
485091 |
2.1.1.107 | R309L |
no transmethylase activity |
485091 |
2.1.1.107 | D47N |
binds about a quarter the quantity of S-adenosyl-L-methionine compared with wild-type, reaction product is only poxidised precorrin-1 |
662638 |
2.1.1.107 | F106A |
considerably less soluble than wild-type, no binding of S-adenosyl-L-methionine, no enzymic activity |
662638 |
2.1.1.107 | L49A |
binds about half the quantity of S-adenosyl-L-methionine compared with wild-type, reaction products are oxidised forms of both precorrin-1 and precorrin-2 |
662638 |