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EC Number Protein Variants Commentary Reference
Show all pathways known for 4.1.3.43Display the reaction diagram Show all sequences 4.1.3.43Y290F mutant generated by site-directed mutagenesis, mutation results in a loss of stereochemical control as the variant is able to utilize substrates with R and S configurations at C4 with similar kinetic parameters 714244
Show all pathways known for 4.1.3.43Display the reaction diagram Show all sequences 4.1.3.43Y290F mutant is able to completely degrade racemic mixtures of 4-hydroxy-2-oxoacids i.e. is not stereospecific 722458
Show all pathways known for 4.1.3.43Display the reaction diagram Show all sequences 4.1.3.43Y290F reduction in channeling efficiency of 30% for all aldehydes tested 721651
Show all pathways known for 4.1.3.43Display the reaction diagram Show all sequences 4.1.3.43Y290S mutant generated by site-directed mutagenesis, mutation results in a loss of stereochemical control as the variant is able to utilize substrates with R and S configurations at C4 with similar kinetic parameters 714244
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