EC Number   |
Protein Variants |
Reference |
|---|
   1.14.15.16 | T416I |
the mutant has reaction specificity similar to human CYP24A1 by also showing the C-23 oxidation pathway |
716274 |
| 1.14.15.16 | T416M |
the mutant also shows the C-23 oxidation pathway |
716274 |
| 1.14.15.16 | T416S |
the metabolic pattern by the mutant remains rat CYP24A1wild type |
716274 |
| 1.14.15.16 | T416V |
the mutant has reaction specificity similar to human CYP24A1 by also showing the C-23 oxidation pathway |
716274 |
| 1.14.15.16 | V391L |
the mutation converts the enzyme from a catabolic 1alpha,25-dihydroxyvitamin-D3-24-hydroxylase into an anabolic 1alpha-hydroxyvitamin-D3-25-hydroxylase. The mutant enzyme retains its basal ability to catabolize 1alpha,25-dihydroxyvitamin D3 via C24 hydroxylation |
717838 |
| 1.14.15.16 | V391L/A326G |
the mutant enzyme continues to form 1alpha,25-dihydroxyvitamin D3 from 1alpha-hydroxyvitamin-D3, but this initial product is diverted via the C23 hydroxylation pathway into 1alpha,25-dihydroxyvitamin-D3-26,23-lactone |
717838 |
| 1.14.15.16 | W210R |
naturally occuring mutation |
736557 |
| 1.14.15.16 | W268X |
naturally occuring mutation |
736557 |
