show all | hide all No of entries

Information on EC 1.14.15.16 - vitamin D3 24-hydroxylase

for references in articles please use BRENDA:EC1.14.15.16
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase.
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
2
reduced adrenodoxin
+
2
+
=
+
2
oxidized adrenodoxin
+
+
2
reduced adrenodoxin
+
2
+
=
+
2
oxidized adrenodoxin
+
Synonyms
24-hydroxylase, 24-ohase, 25-hydroxyvitamin d3-24-hydroxylase, 25-hydroxyvitamin d-24-hydroxylase, 24ohase, vitamin d 24-hydroxylase, vitamin d-24-hydroxylase, p450cc24, cytochrome p450 24a1, 1,25-dihydroxyvitamin d3 24-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = secalciferol + 2 oxidized adrenodoxin + H2O
show the reaction diagram
(2)
-
-
-
calcitriol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O
show the reaction diagram
(1)
-
-
-
PATHWAY SOURCE
PATHWAYS
Select items on the left to see more content.